Changes of gastric ulcer bleeding in the metropolitan area of Japan  

作　　者：Yoko Kubosawa Hideki Mori Satoshi Kinoshita Yoshihiro Nakazato Ai Fujimoto Masahiro Kikuchi Toshihiro Nishizawa Masayuki Suzuki Hidekazu Suzuki 

机构地区：[1]Department of Gastroenterology,National Hospital Organization Tokyo Medical Center,Meguro,Tokyo 152-8902,Japan [2]Division of Gastroenterology and Hepatology,Department of Internal Medicine,Keio University School of Medicine,Shinjuku,Tokyo 160-0016,Japan [3]Department of Clinical and Experimental Medicine,Translational Research Center for Gastrointestinal Diseases(TARGID),University of Leuven,Leuven 3000,Belgium [4]Department of Gastroenterology,Digestive Disease Center,International University of Health and Welfare,Mita Hospital,Minato,Tokyo 108-8329,Japan [5]Division of Gastroenterology and Hepatology,Department of Internal Medicine,Tokai University School of Medicine,Isehara,Kanagawa 259-1193,Japan

出　　处：《World Journal of Gastroenterology》2019年第42期6342-6353,共12页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND The two main causes of gastric ulcer bleeding are Helicobacter pylori(H.pylori)infection and ulcerogenic medicines,although the number of cases caused by each may vary with age.In Japan,the rate of H.pylori infection has fallen over the last decade and the number of prescriptions for non-steroidal anti-inflammatory drugs(NSAIDs)and antithrombotic drugs is increasing as the population ages.Methods of treatment for gastric ulcer bleeding have advanced with the advent of hemostatic forceps and potassium-competitive acid blocker(P-CAB).Thus,causes and treatments for gastric ulcer bleeding have changed over the last decade.AIM To examine the trends of gastric ulcer bleeding over 10 years in the metropolitan area of Japan.METHODS This is a single-center retrospective study.A total of 564 patients were enrolled from inpatients admitted to our hospital with gastric ulcer bleeding between 2006 and 2016.Age,medication history,H.pylori infection,method of treatment,rate of rebleeding,and the length of hospitalization were analyzed.Factors associated with gastric ulcer bleeding were evaluated using Fisher’s exact test,Pearson’s Chi-squared test or Student’s t-test as appropriate.The Jonckheere-Terpstra test was used to evaluate trends.A per-protocol analysis was used to examine the rate of H.pylori infection.RESULTS There was a significant increase in the mean age over time(P<0.01).The rate of H.pylori infection tended to decrease over the study period(P=0.10),whereas the proportion of patients taking antithrombotic agents or NSAIDs tended to increase(P=0.07).Over time,the use of NSAIDs and antithrombotic drugs increased with age.By contrast,the rate of H.pylori infection during the study period fell with age.H.pylori-induced ulcers accounted for the majority of cases in younger patients(<70 years old);however,the rate decreased with age(P<0.01).The method of treatment trend has changed significantly over time.The main method of endoscopic hemostasis has changed from clipping and injection to forceps coagulaBACKGROUND The two main causes of gastric ulcer bleeding are Helicobacter pylori(H. pylori)infection and ulcerogenic medicines, although the number of cases caused by each may vary with age. In Japan, the rate of H. pylori infection has fallen over the last decade and the number of prescriptions for non-steroidal anti-inflammatory drugs(NSAIDs) and antithrombotic drugs is increasing as the population ages.Methods of treatment for gastric ulcer bleeding have advanced with the advent of hemostatic forceps and potassium-competitive acid blocker(P-CAB). Thus,causes and treatments for gastric ulcer bleeding have changed over the last decade.AIM To examine the trends of gastric ulcer bleeding over 10 years in the metropolitan area of Japan.METHODS This is a single-center retrospective study. A total of 564 patients were enrolled from inpatients admitted to our hospital with gastric ulcer bleeding between 2006 and 2016. Age, medication history, H. pylori infection, method of treatment, rateof rebleeding, and the length of hospitalization were analyzed. Factors associated with gastric ulcer bleeding were evaluated using Fisher’s exact test, Pearson’s Chi-squared test or Student’s t-test as appropriate. The Jonckheere-Terpstra test was used to evaluate trends. A per-protocol analysis was used to examine the rate of H. pylori infection.RESULTS There was a significant increase in the mean age over time(P < 0.01). The rate of H. pylori infection tended to decrease over the study period(P = 0.10), whereas the proportion of patients taking antithrombotic agents or NSAIDs tended to increase(P = 0.07). Over time, the use of NSAIDs and antithrombotic drugs increased with age. By contrast, the rate of H. pylori infection during the study period fell with age. H. pylori-induced ulcers accounted for the majority of cases in younger patients(< 70 years old); however, the rate decreased with age(P <0.01). The method of treatment trend has changed significantly over time. The main method of endoscopic hemostasis has changed from

关 键 词：HELICOBACTER PYLORI infection Gastric ULCER bleeding NON-STEROIDAL ANTIINFLAMMATORY drugs ANTITHROMBOTIC agents 

分 类 号：R57[医药卫生—消化系统]