Unexpected encounter of the parasitic kind  

作　　者：Holly Matthews Florian Noulin 

机构地区：[1]Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University

出　　处：《World Journal of Stem Cells》2019年第11期904-919,共16页世界干细胞杂志（英文版）（电子版）

摘　　要：Both parasitology and stem cell research are important disciplines in their own right.Parasites are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortality globally.Stem cell research,on the other hand,focuses on the potential for regenerative medicine for a range of diseases including cancer and regenerative therapies.Though these two topics might appear distant,there are some“unexpected encounters”.In this review,we summarise the various links between parasites and stem cells.First,we discuss how parasites’own stem cells represent interesting models of regeneration that can be translated to human stem cell regeneration.Second,we explore the interactions between parasites and host stem cells during the course of infection.Third,we investigate from a clinical perspective,how stem cell regeneration can be exploited to help circumvent the damage induced by parasitic infection and its potential to serve as treatment options for parasitic diseases in the future.Finally,we discuss the importance of screening for pathogens during organ transplantation by presenting some clinical cases of parasitic infection following stem cell therapy.Both parasitology and stem cell research are important disciplines in their own right. Parasites are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortality globally. Stem cell research, on the other hand, focuses on the potential for regenerative medicine for a range of diseases including cancer and regenerative therapies. Though these two topics might appear distant, there are some "unexpected encounters". In this review, we summarise the various links between parasites and stem cells. First,we discuss how parasites’ own stem cells represent interesting models of regeneration that can be translated to human stem cell regeneration. Second, we explore the interactions between parasites and host stem cells during the course of infection. Third, we investigate from a clinical perspective, how stem cell regeneration can be exploited to help circumvent the damage induced by parasitic infection and its potential to serve as treatment options for parasitic diseases in the future. Finally, we discuss the importance of screening for pathogens during organ transplantation by presenting some clinical cases of parasitic infection following stem cell therapy.

关 键 词：Stem cells Parasites TRANSPLANTATION THERAPEUTIC HOST PATHOGEN interactions 

分 类 号：R73[医药卫生—肿瘤]