Incidence of anastomotic stricture after Ivor-Lewis oesophagectomy using a circular stapling device  

作　　者：Robert Tyler Amit Nair Meagan Lau James Hodson Rizwan Mahmood Jan Dmitrewski 

机构地区：[1]Department of Upper Gastrointestinal Surgery,University Hospitals Birmingham NHS Foundation Trust,Birmingham B152TH,United Kingdom [2]Institute of Translational Medicine,University Hospitals Birmingham NHS Foundation Trust,Birmingham B152TH,United Kingdom [3]Department of Gastroenterology,Russells Hall Hospital,Dudley DY12HQ,United Kingdom

出　　处：《World Journal of Gastrointestinal Surgery》2019年第11期407-413,共7页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Benign oesophageal strictures carry a significant level of morbidity,causing burdensome symptoms impacting on quality of life.Post-oesophagectomy anastomotic stricture rates as high as 41%have been reported in the literature.These can require endoscopic dilatation,often multiple times to relieve dysphagia.The aim of the present study was to determine a single surgeons stricture rate in a series of 2-stage Ivor-Lewis procedures,and to identify any independent risk factors in their development.AIM To determine a single surgeons stricture rate in a series of 2-stage Ivor-Lewis procedures,and to identify any independent risk factors in their development.METHODS We performed a retrospective analysis of a prospectively collected database of Ivor-Lewis oesophagectomy performed from 2004-2018 to determine the stricture rate.The database comprised a single-surgeon series of open,two-stage oesophagectomies with a circular stapled intra-thoracic anastomosis.Tumour location,histology,neoadjuvant chemotherapy,stapler size,T-stage and R-status were analysed to see if they could predict stricture formation.Stricture was defined as dysphagia requiring endoscopic dilatation.Patients with anastomotic leaks were excluded on the basis they would develop an anastomotic stricture.RESULTS One hundred and seventy patients were collected in the database.Nineteen were excluded on the basis of anastomotic leak,perioperative death and early recurrence.One hundred and fifty-four patients(119 males,35 females)with a mean age of 64±10 years were eligible for analysis.A total of 15 patients developed strictures a median of 99 d(interquartile range:84-133)after surgery,giving a Kaplan-Meier estimated stricture rate of 10%at one year.None of the factors considered were found to be significantly associated with strictures.CONCLUSION In this study the stricture rate was 10%,with the majority occurring in the first 100 d after surgery.No significant independent factors were found in the development of strictures.BACKGROUND Benign oesophageal strictures carry a significant level of morbidity, causing burdensome symptoms impacting on quality of life. Post-oesophagectomy anastomotic stricture rates as high as 41% have been reported in the literature.These can require endoscopic dilatation, often multiple times to relieve dysphagia. The aim of the present study was to determine a single surgeons stricture rate in a series of 2-stage Ivor-Lewis procedures, and to identify any independent risk factors in their development.AIM To determine a single surgeons stricture rate in a series of 2-stage Ivor-Lewis procedures, and to identify any independent risk factors in their development.METHODS We performed a retrospective analysis of a prospectively collected database of Ivor-Lewis oesophagectomy performed from 2004-2018 to determine the stricture rate. The database comprised a single-surgeon series of open, two-stage oesophagectomies with a circular stapled intra-thoracic anastomosis. Tumour location, histology, neoadjuvant chemotherapy, stapler size, T-stage and R-status were analysed to see if they could predict stricture formation. Stricture was defined as dysphagia requiring endoscopic dilatation. Patients with anastomotic leaks were excluded on the basis they would develop an anastomotic stricture.RESULTS One hundred and seventy patients were collected in the database. Nineteen were excluded on the basis of anastomotic leak, perioperative death and early recurrence. One hundred and fifty-four patients(119 males, 35 females) with a mean age of 64 ± 10 years were eligible for analysis. A total of 15 patients developed strictures a median of 99 d(interquartile range: 84-133) after surgery,giving a Kaplan-Meier estimated stricture rate of 10% at one year. None of the factors considered were found to be significantly associated with strictures.CONCLUSION In this study the stricture rate was 10%, with the majority occurring in the first100 d after surgery. No significant independent factors were found in the development of strictu

关 键 词：OESOPHAGEAL cancer ANASTOMOSIS STRICTURE Stapled CIRCULAR 

分 类 号：R73[医药卫生—肿瘤]