Comparison of intra-articular injection of parecoxib vs oral administration of celecoxib for the clinical efficacy in the treatment of early knee osteoarthritis  

作　　者：Lu Lu Yu Xie Ke Gan Xiao-Wen Huang 

机构地区：[1]Department of Rheumatology,Affiliated Hospital of Nanjing University of Chinese Medicine(Jiangsu Province Hospital of Chinese Medicine),Nanjing 210029,Jiangsu Province,China [2]Department of Orthopedics,First Affiliated Hospital of Nanjing Medical University(Jiangsu Province Hospital),Nanjing 210029,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2019年第23期3971-3979,共9页世界临床病例杂志

基　　金：National Natural Science Foundation of China,NO.81774274;Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine,NO.Y19058

摘　　要：BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs)have played a crucial role in the treatment of osteoarthritis,especially in the early stages.However,the cardiovascular risk and adverse gastrointestinal reactions of oral NSAIDs in elderly people cannot be underestimated.Intra-articular injection of NSAIDs may be a new attempt for early knee osteoarthritis treatment.Parecoxib may be a suitable drug for intra-articular injection.AIM To observe the clinical efficacy of the intra-articular injection of parecoxib for early knee osteoarthritis.METHODS Early knee osteoarthritis patients(n=110)were retrospectively analyzed.These patients were divided into three groups:Basic treatment+oral glucosamine(group A,n=37),oral celecoxib+basic treatment+oral glucosamine(group B,n=37),and intra-articular injection of parecoxib+basic treatment+oral glucosamine(group C,n=36).Intra-articular injection of parecoxib was performed once every 2 wk at a dose of 40 mg each time,for three times total.The three groups were compared in terms of visual analogue scale(VAS)scores,Hospital for Special Surgery(HSS)scores and patient satisfaction before and after treatment.The levels of inflammatory cytokines in the synovial fluid were detected in the three groups before and after treatment.RESULTS All patients were followed up for an average of 15.5±2.7 mo.The clinical efficacy was estimated by VAS and HSS scores at 12 mo after treatment.Inflammatory cytokine levels in the synovial fluid were evaluated at 3 mo after treatment.VAS and HSS scores were significantly improved in each group compared with before(P<0.001).There were significant differences among the three groups in VAS and HSS scores(P<0.001).The clinical efficacy of group C was superior to that of groups A and B(P<0.001),while group B outperformed group A in this respect(P<0.001).The patient satisfaction was the highest in group C(P<0.001).After treatment,the levels of tumor necrosis factorα(TNF-α)and interleukin(IL)-6 in the synovial fluid decreased in each group compared with BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs) have played a crucial role in the treatment of osteoarthritis, especially in the early stages. However, the cardiovascular risk and adverse gastrointestinal reactions of oral NSAIDs in elderly people cannot be underestimated. Intra-articular injection of NSAIDs may be a new attempt for early knee osteoarthritis treatment. Parecoxib may be a suitable drug for intra-articular injection.AIM To observe the clinical efficacy of the intra-articular injection of parecoxib for early knee osteoarthritis.METHODS Early knee osteoarthritis patients(n = 110) were retrospectively analyzed. These patients were divided into three groups: Basic treatment + oral glucosamine(group A, n = 37), oral celecoxib + basic treatment + oral glucosamine(group B, n= 37), and intra-articular injection of parecoxib + basic treatment + oral glucosamine(group C, n = 36). Intra-articular injection of parecoxib was performed once every 2 wk at a dose of 40 mg each time, for three times total. The three groups were compared in terms of visual analogue scale(VAS) scores,Hospital for Special Surgery(HSS) scores and patient satisfaction before and after treatment. The levels of inflammatory cytokines in the synovial fluid were detected in the three groups before and after treatment.RESULTS All patients were followed up for an average of 15.5 ± 2.7 mo. The clinical efficacy was estimated by VAS and HSS scores at 12 mo after treatment. Inflammatory cytokine levels in the synovial fluid were evaluated at 3 mo after treatment. VAS and HSS scores were significantly improved in each group compared with before(P < 0.001). There were significant differences among the three groups in VAS and HSS scores(P < 0.001). The clinical efficacy of group C was superior to that of groups A and B(P < 0.001), while group B outperformed group A in this respect(P < 0.001). The patient satisfaction was the highest in group C(P < 0.001). After treatment, the levels of tumor necrosis factor α(TNF-α) and interleukin(IL)-6

关 键 词：Knee OSTEOARTHRITIS INTRA-ARTICULAR injection PARECOXIB NON-STEROID ANTIINFLAMMATORY drugs 

分 类 号：R97[医药卫生—药品]