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Flurbiprofen microneedle patches for the management of acute postoperative pain: 《Nano Research》2024年第8期7493-7503,共11页Huaqing Chu Yanyan Zhang Yuan Yang Jiangtao Xue Cong Li Wei Zhang Zhou Li Hui Zheng; the National Key Research and Development Program of China(Nos.2022YFB3205602 and 2022YFB3804703);the National Natural Science Foundation of China(Nos.52372174,61875015,and T2125003);the Beijing Natural Science Foundation(Nos.L212046 and L212010);the Fundamental Research Funds for the Central Universities;the Animal Experimentation Ethics Committee of the Cancer Hospital,Chinese Academy of Medical Sciences(Ethical Approval No.NCC2023A291).; Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are suboptimal.This study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel...; 关键词：MICRONEEDLE postoperative pain FLURBIPROFEN non-steroid anti-inflammatory drug cross-linked gelatin

Effectiveness of a Single High Dose of Platelet-Rich Plasma (PRP) Injection Over Corticosteroid and Hyaluronic Acid Injections on Osteoarthritis, Chronic Tendinitis and Tennis Elbow Treatment: 《Open Journal of Regenerative Medicine》2022年第2期41-53,共13页Charbel Khalil Diana Chaker Albert Azar Elie El Kayem Rawad Salameh Mohamad Dar-Yahya Fadi Nader Alain Chebly Kamil Samaha Ahmad Ibrahim; Background: Corticosteroid, hyaluronic acid (HA) injections and Anti-inflammatory agents are considered as non-invasive treatments for knee osteoarthritis (OA), Chronic Tendinitis (CT) and Tennis elbow (TE) that are s...; 关键词：Platelet Rich Plasma (PRP) OSTEOARTHRITIS Chronic Tendinitis Tennis Elbow CORTICOSTEROID Hyaluronic Acid Non-Steroid Anti-Inflammatory

Protective mechanism of rebamipide on non-steroid anti-inflammatory drug related small intestinal mucosal injury: 《China Medical Abstracts(Internal Medicine)》2021年第3期171-172,共2页HAN Taotao; Objective To explore the protective effect and related mechanism of rebamipide on nonsteroid anti-inflammatory drug(NSAID)related small intestinal mucosal injury.Methods A total of 21 C57BL/6 mice were selected and by...; 关键词：C57BL/6 DRUG NSAID INFLAMMATORY

Comparison of intra-articular injection of parecoxib vs oral administration of celecoxib for the clinical efficacy in the treatment of early knee osteoarthritis被引量：14: 《World Journal of Clinical Cases》2019年第23期3971-3979,共9页Lu Lu Yu Xie Ke Gan Xiao-Wen Huang; National Natural Science Foundation of China,NO.81774274;Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine,NO.Y19058; BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs)have played a crucial role in the treatment of osteoarthritis,especially in the early stages.However,the cardiovascular risk and adverse gastrointestinal reactions...; 关键词：Knee OSTEOARTHRITIS INTRA-ARTICULAR injection PARECOXIB NON-STEROID ANTIINFLAMMATORY drugs

Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs被引量：3: 《Acta Biochimica et Biophysica Sinica》2014年第9期774-781,共8页Xue Sun Jun Jin Ji-Gang Zhang Lin Qi Frank Karl Braun Xing-Ding Zhang Feng Xu; Non-steroid anti-inflammatory drugs （NSAIDs） are general- ly used in the treatment of inflammation and pain through cyclooxygenase （COX） inhibition. Mounting evidence has indicated additional COX-independent targe...; 关键词：acid-sensing ion channel （ASIC） intervertebraldisknucleus pulposus cells non-steroid anti-inflammatorydrug （NSAID） IBUPROFEN

Synthesis and anti-HBV evaluation of mono L-amino acid ester, mono non-steroid anti-inflammation drug carboxylic ester derivatives of acyclonucleoside phosphonates被引量：1: 《Chinese Chemical Letters》2014年第1期115-118,共4页Xiao-Zhong Fu Feng-Jie Jiang Yu Ou Sheng Fu Yu-Feng Cha Shun Zhang Zong-Yuan Liu Wen Zhou Ai-Min Wang Yong-Lin Wang; supported by the National Natural Science Foundation of China(Nos.20962004,81260473);Projects of Guizhou Science and Technology Department(Nos.2013-3031,2012-3013);Excellent Youth Scientific Talents Foundation of Guizhou(No.2013-45); A series of mono L-amino acid ester, mono non-steroid anti-inflammation drug （NSAID）, carboxylic ester derivatives of acyclonucleoside phosphonates were prepared by using a ＂one pot synthesis＂ method and their in ...; 关键词：Acyclonucleoside phosphonate Non-steroid anti-inflammation drug Anti-HBV activity

Rebamipide suppresses diclofenac-induced intestinal permeability via mitochondrial protection in mice被引量：8: 《World Journal of Gastroenterology》2012年第10期1059-1066,共8页Lei Diao Qiao Mei Jian-Ming Xu Xiao-Chang Liu Jing Hu Juan Jin Qiang Yao Mo-Li Chen; AIM: To investigate the protective effect and mechanism of rebamipide on small intestinal permeability induced by diclofenac in mice. METHODS: Diclofenac (2.5 mg/kg) was administered once daily for 3 d orally. A contr...; 关键词：Intestinal mucosal permeability MITOCHONDRIA Non-steroid anti-inflammatory drugs Oxidative damage REBAMIPIDE Tight junction

Effects of chronic therapy with non-steroideal antinflammatory drugs on gastric permeability of sucrose: A study on 71 patients with rheumatoid arthritis: 《World Journal of Gastroenterology》2006年第31期5017-5020,共4页Marta Maino Nicola Mantovani Roberta Merli Giulia Martina Cavestro Gioacchino Leandro Lucas Giovanni Cavallaro Vincenzo Corrente Veronica Iori Alberto Pilotto Angelo Franzè Francesco Di Mario; AIM： To evaluate the gastric permeability after both acute and chronic use of non-steroidal anti-inflammatory drugs （NSAIDs） and to assess the clinical usefulness of sucrose test in detecting and following NSAIDs-i...; 关键词：Non-steroidal anti inflammatory drugs Gastric mucosal permeability Gastrointestinal toxicity Sucrose test PANTOPRAZOLE

Transdermal Iontophoresis of Non-steroid Anti-inflamma-tory Drugs被引量：1: 《Journal of Chinese Pharmaceutical Sciences》1997年第1期54-56,共3页For Master′s Degree: Jian Qing Gao Supervisor: Prof. Wen Quan Liang Department of Pharmaceutics, Zhejiang Medical University, Hangzhou 310006 Keywords Iontophoresis Percutaneous permeation Non steroid anti inflammatory drugs; ＴｒａｎｓｄｅｒｍａｌＩｏｎｔｏｐｈｏｒｅｓｉｓｏｆＮｏｎ┐ｓｔｅｒｏｉｄＡｎｔｉ┐ｉｎｆｌａｍｍａ┐ｔｏｒｙＤｒｕｇｓＦｏｒＭａｓｔｅｒ′ｓＤｅｇｒｅｅ：Ｊｉａｎ－ＱｉｎｇＧａｏＳｕｐｅｒｖｉｓｏｒ：Ｐｒｏｆ．Ｗｅ...; 关键词：非类固醇抗炎药经皮渗透透气吸收离子电渗疗法

TOXICOLOGICAL STUDR OF DL-111-IT,A NEW NON-STEROID EARLY PREGNANCY TERMINATING AGENT: 《Journal of Reproduction and Contraception》1989年第1期48-48,50,共2页FANGRui-Ying ZHOUHui-Jun YANGBao-Zhu LIUHe-Chu XUJian-Hua LOUYi-Jia ZHANGYuan-Pei; DL-111-IT (3-ethylpheny1-5- (3-methoxyphenyl) -1, 2, 4-triazole) is highly effective for terminating early pregnancy in several species of animals without delayoel embryotoxic and teratogenic effects on the secondary ...; 关键词：DL-111-IT 类固醇早期怀孕妊娠终止引产药

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