Flurbiprofen microneedle patches for the management of acute postoperative pain  

作　　者：Huaqing Chu Yanyan Zhang Yuan Yang Jiangtao Xue Cong Li Wei Zhang Zhou Li Hui Zheng 

机构地区：[1]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [2]Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 101400,China [3]Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases,School of Integrated Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha 410208,China [4]School of Life Science,Institute of Engineering Medicine,Beijing Institute of Technology,Beijing 100081,China [5]Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Nano Research》2024年第8期7493-7503,共11页纳米研究（英文版）

基　　金：the National Key Research and Development Program of China(Nos.2022YFB3205602 and 2022YFB3804703);the National Natural Science Foundation of China(Nos.52372174,61875015,and T2125003);the Beijing Natural Science Foundation(Nos.L212046 and L212010);the Fundamental Research Funds for the Central Universities;the Animal Experimentation Ethics Committee of the Cancer Hospital,Chinese Academy of Medical Sciences(Ethical Approval No.NCC2023A291).

摘　　要：Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are suboptimal.This study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel).By adding varying amounts of genipin to modulate the crosslinking degree of cGel,the drug release behavior of the drug-loaded MNs in the skin can be altered.The crosslinking parameters that meet therapeutic requirements are selected,thus providing rapid and longlasting analgesic effects.cGel solutions were successfully cross-linked,altering matrix material microstructure,confirmed by scanning electron microscope imaging and fourier transform infrared spectroscopy.MNs demonstrated increasing mechanical strength with higher crosslinking.Drug release rates were rapid initially,then slowed,exhibiting a characteristic of decreased release rates with increasing degrees of crosslinking.In vivo,FBP/cGel MNs significantly reduced allodynia and hyperalgesia post-surgery,with the greatest effect observed at 2–3 h post-surgery,and can maintain analgesia for up to 6 h.Biosafety tests confirmed good biocompatibility.FBP/cGel MNs effectively penetrate the stratum corneum,safely delivering drugs with significant analgesic effects,excellent mechanical properties,and good biocompatibility,representing a promising strategy for managing acute postoperative pain.

关 键 词：MICRONEEDLE postoperative pain FLURBIPROFEN non-steroid anti-inflammatory drug cross-linked gelatin 

分 类 号：R402[医药卫生—临床医学]