A Numerical Study of Passive Receptor-Mediated Endocytosis of Nanoparticles:The Effect of Mechanical Properties  

作　　者：Xinyue Liu Yunqiao Liu Xiaobo Gong Huaxiong Huang 

机构地区：[1]Key Laboratory of Hydrodynamics(Ministry of Education),Department of Engineering Mechanic,School of Naval Architecture,Ocean and Civil Engineering,Shanghai Jiao Tong University,Shanghai,200240,China. [2]Department of Mathematics and Statistics,York University,Toronto,Ontario,M3J1P3,Canada.

出　　处：《Computer Modeling in Engineering & Sciences》2018年第8期281-300,共20页工程与科学中的计算机建模（英文）

基　　金：This work was supported by the National Natural Science Foundations of China(11372191,11232010);the Natural Science and Engineering Research Council of Canada.

摘　　要：In this work,a three-dimensional axisymmetric model with nanoparticle,receptor-ligand bonds and cell membrane as a system was used to study the quasi-static receptor-mediated endocytosis process of spherical nanoparticles in drug delivery.The minimization of the system energy function was carried out numerically,and the deformations of nanoparticle,receptor-ligand bonds and cell membrane were predicted.Results show that passive endocytosis may fail due to the rupture of receptor-ligand bonds during the wrapping process,and the size and rigidity of nanoparticles affect the total deformation energy and the terminal wrapping stage.Our results suggest that,in addition to the energy requirement,the success of passive endocytosis also depends on the maximum strength of the receptor-ligand bonds.

关 键 词：RECEPTOR-MEDIATED ENDOCYTOSIS NANOPARTICLE UPTAKE optimization method receptor-ligand BONDS drug delivery 

分 类 号：TB3[一般工业技术—材料科学与工程]