肠道菌群在神经精神疾病中的作用  

Role of Intestinal Microbiota in Neuropsychiatric Diseases

作　　者：周峰 周志强 嵇晴 ZHOU Feng;ZHOU Zhiqiang;JI Qing(Department of Anesthesiology,Clinical College of Medical School of Nanjing University/General Hospital of Eastern Theater Command,People′s Liberation Army,Nanjing 210002,China)

机构地区：[1]南京大学医学院临床学院东部战区总医院麻醉科

出　　处：《医学综述》2019年第23期4690-4695,共6页Medical Recapitulate

基　　金：国家自然科学基金(81571083)

摘　　要：神经精神疾病包括重度抑郁症、阿尔茨海默病、创伤后应激障碍和儿童多动症等,严重影响了患者的生存质量,造成巨大的经济损失。其病因尚无定论,除遗传和环境因素外,肠道菌群可能是导致神经精神疾病的潜在原因之一。肠道菌群通过多种方式与大脑连接,因此其被视为大脑与肠道双向通讯系统的重要承担者(脑-肠轴),这也为肠道菌群在神经精神障碍发病中的重要作用提供了有力支持。目前,肠道菌群已成为治疗神经精神疾病的研究热点。未来,肠道菌群将联合现有传统治疗手段不断丰富神经精神疾病的治疗。Neuropsychiatric diseases including major depression,Alzheimer′s disease,post-traumatic stress disorder and childhood hyperactivity disorder,have seriously affected the quality of life of the patients and caused huge economic losses.The cause is still inconclusive:in addition to genetic and environmental factors,intestinal microbiota may be one of the potential causes of neuropsychiatric diseases.Intestinal microbiota connects to the brain in many ways,so it is considered to be an important bearer of the two-way communication system between the brain and the intestine(brain-gut axis),which also provides strong support for the important role of intestinal microbiota in the pathogenesis of neuropsychiatric disorders.At present,the intestinal microbiota has become a research hotspot for the treatment of neuropsychiatric diseases.In the future,the intestinal microbiota combined with existing traditional treatments will continue to enrich the treatment of neuropsychiatric diseases.

关 键 词：抑郁症 阿尔茨海默病 创伤后应激障碍 多动症 肠道菌群 脑-肠轴 

分 类 号：R74[医药卫生—神经病学与精神病学]