A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance  

作　　者：Caixia Gong Zhenhuan Ouyang Weiqiao Zhao Jie Wang Kun Li Peipei Zhou Ting Zhao Nenggan Zheng Zhefeng Gong 

机构地区：[1]Department of Neurobiology,Key Laboratory of Medical Neurobiology of the Ministry of Health of China,Key Laboratory of Neurobiology,Zhejiang University School of Medicine,Hangzhou 310058,China [2]Qiushi Academy for Advanced Studies,Zhejiang University,Hangzhou 310007,China [3]Janelia Research Campus,Howard Hughes Medical Institute,Ashburn,VA 22011,USA

出　　处：《Neuroscience Bulletin》2019年第6期959-968,共10页神经科学通报（英文版）

基　　金：supported by grants from the National Basic Research Development Program of China (973 Program, 2013CB945603);the National Natural Science Foundation of China (31070944, 31271147, 31471063, 31671074, and 61572433);the Natural Science Foundation of Zhejiang Province, China (LR13C090001 and LZ14F020002);the Fundamental Research Funds for the Central Universities, China (2017FZA7003)

摘　　要：When facing a sudden danger or aversive condition while engaged in on-going forward motion,animals transiently slow down and make a turn to escape.The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown.Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons(the PET pathway). Inhibiting neurons in the PET pathway led to defects in lightavoidance due to insufficient deceleration and head casting.On the other hand, activation of PET pathway neurons specifically caused immediate deceleration in larval locomotion. Our findings reveal a neural substrate for the emergent deceleration response and provide a new understanding of the relationship between behavioral modules in animal avoidance responses.When facing a sudden danger or aversive condition while engaged in on-going forward motion,animals transiently slow down and make a turn to escape.The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown.Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons(the PET pathway). Inhibiting neurons in the PET pathway led to defects in lightavoidance due to insufficient deceleration and head casting.On the other hand, activation of PET pathway neurons specifically caused immediate deceleration in larval locomotion. Our findings reveal a neural substrate for the emergent deceleration response and provide a new understanding of the relationship between behavioral modules in animal avoidance responses.

关 键 词：DROSOPHILA Larva DECELERATION Light avoidance EH neurons PTTH neurons Tdc2 motor neurons 

分 类 号：R74[医药卫生—神经病学与精神病学]