绿豆对高脂饮食大鼠肠道微生物及脂代谢调节的影响  

Effects of mung bean on intestinal microflora and lipid metabolism in rats fed with a high-fat diet

作　　者：刘丹丹 管骁[1] 黄凯 李森[1] 刘静[2] 于文文 段瑞谦 LIU Dandan;GUAN Xiao;HUANG Kai;LI Sen;LIU Jing;YU Wenwen;DUAN Ruiqian(School of Medical Instruments and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;College of Information Engineering, Shanghai Maritime University, Shanghai 200135, China)

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海海事大学信息工程学院,上海200135

出　　处：《工业微生物》2019年第6期26-31,共6页Industrial Microbiology

基　　金：国家重点研究开发计划(2017YFD040120、2017YFD040102);国家自然科学基金(31701515);长江三角洲合作项目(18395810200)

摘　　要：本文研究并评估了绿豆对高脂饮食大鼠血脂代谢(TG、TC、LDL-C、HDL-C)、肝脏脂质分布、抗氧化酶活性(SOD、CAT、T-AOC)的影响。还研究了绿豆对高脂饮食大鼠肠道微生物菌群及短链脂肪酸(SCFAs)的调节作用。结果表明,与高脂饮食组相比,添加绿豆显著减轻大鼠了血清和肝脏的脂质积累,并提高了抗氧化酶的活性。大鼠盲肠中的SCFAs含量随绿豆剂量的增加而增加。大鼠盲肠内容物以厚壁菌和拟杆菌为主。绿豆摄入影响了大鼠肠道微生物群的丰度,拟杆菌和放线菌相对丰度等增加。这些结果表明,绿豆具有改善肠道微生物及调节脂代谢的作用,对机体有显著的保护作用。The effects of mung bean on lipid metabolism(TG,TC,LDL-C,HDL-C),liver lipid distribution and antioxidant enzyme activities(SOD,CAT,T-AOC)in rats fed with high-fat diet were investigated and evaluated,including the regulatory effects of mung bean on intestinal microflora and short-chain fatty acids(SCFAs)in rats fed with high-fat diet.The results showed that the addition of mung bean significantly reduced lipid accumulation in serum and liver and increased the activity of antioxidant enzymes,if compared with those of the high-fat diet group.The content of SCFAs in cecum of rats increased with the increase of mung bean dosage.The contents of cecum in rats were mainly Firmicutes and Bacteroidetes.Mung bean intake affected the abundance of intestinal microflora in rats,and the relative abundance of Bacteroidetes and Actinbacteria increased.These results indicated that the mung bean could improve intestinal microorganisms,regulate lipid metabolism and had a significant protective effect on the body.

关 键 词：绿豆 肠道微生物 脂代谢 

分 类 号：R28[医药卫生—中药学]