帕金森病异动症与患者营养状况和用药的相关性分析  

Correlation analysis between the dyskinesia in Parkinson’s disease and nutritional status as well as medications

作　　者：刘忆[1] 詹贞 杨天婷[1] 胡秀秀[1] 董靖德[1] LIU Yi;ZHAN Zhen;YANG Tian-ting(Department of Geriatric Neurology,Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院老年神经科

出　　处：《临床神经病学杂志》2019年第6期419-422,共4页Journal of Clinical Neurology

基　　金：南京市医学科技发展一般性课题(YKK15108)

摘　　要：目的研究帕金森病(PD)患者异动症与营养状况和用药之间的关系。方法选取在我院2015年1月至2017年4月住院的PD异动症患者进行回顾性分析,将该组患者与同期住院的年龄、性别、病程无统计学差异且未发生异动症的PD患者进行1∶1匹配,并对两组患者的营养指标、单位体质量单日抗PD用药剂量等指标进行独立样本t检验检测。并将上述指标与异动症进行单因素Logistic回归分析和多因素条件Logistic回归分析。结果异动症组体质量和血前白蛋白水平均较非异动症组明显降低,异动症组单位体质量单日左旋多巴、普拉克索、吡贝地尔剂量均显著高于非异动症组(均P<0.05)。但仅有单位体质量单日左旋多巴和吡贝地尔剂量高是左旋多巴所致PD异动症患者的危险因素。结论单位体质量单日高剂量左旋多巴和单位体质量单日高剂量吡贝地尔是发生异动症的危险因素。加强营养管理及营养支持可能减轻体质量的下降和减少异动症的发生。Objective To investigate the relationship between dyskinesia in Parkinson’s disease(PD) and nutritional status as well as medications.Methods The clinical data of PD inpatients with dyskinesia and those without dyskinesia in our hospital from January 2015 to April 2017 were analyzed retrospectively. These two groups had no statistic difference in age, sex, and course of disease. Nutritional status and daily doses of antiparkinsonian drugs per kilogram body weight were analysed by using independent t-test.The association between those index and dyskinesia were studyed with univariate and conditional multivariate Logistic regression analysis.Results Weight and prealbumin levels in the dyskinesia group were significantly lower than those in the non-dyskinesia group, and the daily doses of levodopa, pramipexole, and piribedil per kilogram body weight in the dyskinesia group were significantly higher than those in the non dyskinesia group(allP>0.05). However, high daily dose of levodopa and piribedil per kilogram body weight were only two risk factors for PD patients with dyskinesia.Conclusions The daily high dose levodopa and piribedil per kilogram body weight are risk factors associated with PD dyskinesia. Improving nutrition management and nutritional support may reduce weight loss and dyskinesia risk.

关 键 词：帕金森病 异动症 营养 药物治疗 危险因素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]