三乙烯二胺催化合成3-(二苯基磷酰基)-1?3-二苯基丙-1-酮  

Synthesis of 3-(diphenylphosphoryl)-1?3-diphenylpropan-1- one catalyzed by 1?4-diazabicyclo[2.2.2]octane

作　　者：方芙容 柴南南 祝婷婷 李雪枫[1] 刘斌[1,2] FANG Fu-rong;CHAI Nan-nan;ZHU Ting-ting;LI Xue-feng;LIU Bin(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xi'an 712046,China;Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Xi'an 712046,China)

机构地区：[1]陕西国际商贸学院医药学院,陕西西安712046 [2]陕西省中药绿色制造技术协同创新中心,陕西西安712046

出　　处：《精细与专用化学品》2019年第12期24-27,共4页Fine and Specialty Chemicals

基　　金：2019年陕西省大学生创新创业项目(S201913123011);陕西国际商贸学院“中药药效物质研究”创新团队(SSY18TD01)

摘　　要：以查尔酮和二苯基氧膦为原料,在三乙烯二胺(DABCO)催化下发生Michael加成反应得到3-(二苯基磷酰基)-1,3-二苯基丙-1-酮,产物结构通过~1HNMR和ESI-MS确定。对反应条件进行研究,确定该Michael加成反应的最佳条件为:物料比n(查尔酮)∶n(二苯基氧膦)=1.5∶1,n(DABCO)∶n(二苯基氧膦)=0.3∶1,反应溶剂为二氯甲烷,反应时间为9h。在此最佳条件下,产物收率为91.3%。3-(Diphenylphosphoryl)-1,3-diphenylpropan-1-one was synthesized from chalcone and diphenylphosphine oxide by Michael addition reaction with 1,4-diazabicyclo[2.2.2]octane(DABCO)as catalyst.The structure of the product was confirmed by^1HNMR and ESI-MS.The optimal reaction conditions of the Michael addition reaction were also investigated:the mole ratio of chalcone and diphenylphosphine oxide was 1.5∶1;the dosage of DABCO was n(DABCO)∶n(diphenylphosphine oxide)=0.3∶1;dichloromethane as solvent;the reaction time was 9 h.Target compound was obtained in a yield of 91.3%by the optimal reaction conditions.

关 键 词：有机磷化合物 查尔酮 MICHAEL加成反应 三乙烯二胺 合成 

分 类 号：TQ463[化学工程—制药化工]