Impact of IL-18 gene promoter polymorphisms on renal cell carcinoma occurrence and prognosis in Chinese Han population  

作　　者：Shaojun Nong Yangbo Guan Zhongqing Wei Yueping Zhang Bin Cheng Chongsheng He Limin Ma Shujun Zhou Wenguang Li Jian Ni Zhiwei Wang 

机构地区：[1]Department of Urological Surgery,The Affiliated Hospital of Nantong University,Nantong 226001,China [2]Department of Urological Surgery,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China

出　　处：《Oncology and Translational Medicine》2019年第6期278-284,共7页肿瘤学与转化医学（英文版）

基　　金：Supported by grants from the China Postdoctoral Science Foundation(No.2014M139951);the Science and Technology Project of Nantong,Jiangsu Province(No.MS22016043)

摘　　要：Objective Genetic polymorphisms in various inflammatory cytokines have been associated with the risk and growth or invasiveness of renal cell carcinoma(RCC).However,the molecular basis of RCC pathogenesis is unclear.The aim of this study was to explore a possible association between two IL-18 gene promoter polymorphisms,-137G/C and -607 C/A,and RCC occurrence and prognosis in a Chinese Han population.Methods Chinese Han patients with RCC(n=175) and age-matched healthy controls(n=200) were analyzed by single nucleotide polymorphism genotyping during follow-up.Results IL-18-137G allele frequency was significantly higher in patients with lymph node metastasis(Odds ratio [OR],3.52;95% confidence interval [CI],0.97-16.17;P=0.045).The IL-18-607 CC genotype was associated with distant metastasis(OR,2.81;95% CI,1.35-6.24;P=0.025).The IL-18-137G allele was correlated with more advanced tumor stage(OR,1.83;95% CI,1.05-3.72;P=0.026) and higher tumor grade(OR,2.23;95% CI,0.78-4.12;P=0.041).The IL-18-607 CC genotype frequency was significantly higher in patients with more advanced cancer stage(OR,2.92;95% CI,1.80-6.87;P=0.001) and higher tumor grade(OR,2.21;95% CI,1.25-12.25;P=0.035).The IL-18-607 allele was associated with more advanced cancer stage(OR,2.47;95% CI,1.38-3.83;P=0.002).Carriers of the GG genotype with the -137G/C polymorphism had a 2.165-times higher risk of RCC progression than carriers of the GC genotype(Hazard ratio=2.15,95% CI,1.270-3.687).Conclusion The IL-18-137G allele was correlated with more advanced stage,higher tumor grade,and lymph node metastasis.IL-18 gene promoter polymorphism -137G/C may thus influence the prognosis of RCC patients.Objective Genetic polymorphisms in various inflammatory cytokines have been associated with the risk and growth or invasiveness of renal cell carcinoma(RCC). However, the molecular basis of RCC pathogenesis is unclear. The aim of this study was to explore a possible association between two IL-18 gene promoter polymorphisms, –137G/C and –607 C/A, and RCC occurrence and prognosis in a Chinese Han population. Methods Chinese Han patients with RCC(n = 175) and age-matched healthy controls(n = 200) were analyzed by single nucleotide polymorphism genotyping during follow-up. Results IL-18-137G allele frequency was significantly higher in patients with lymph node metastasis(Odds ratio [OR], 3.52; 95% confidence interval [CI], 0.97–16.17; P = 0.045). The IL-18-607 CC genotype was associated with distant metastasis(OR, 2.81; 95% CI, 1.35–6.24; P = 0.025). The IL-18-137G allele was correlated with more advanced tumor stage(OR, 1.83; 95% CI, 1.05–3.72; P = 0.026) and higher tumor grade(OR, 2.23; 95% CI, 0.78–4.12; P = 0.041). The IL-18-607 CC genotype frequency was significantly higher in patients with more advanced cancer stage(OR, 2.92; 95% CI, 1.80–6.87; P = 0.001) and higher tumor grade(OR, 2.21; 95% CI, 1.25–12.25; P = 0.035). The IL-18-607 allele was associated with more advanced cancer stage(OR, 2.47; 95% CI, 1.38–3.83; P = 0.002).Carriers of the GG genotype with the –137G/C polymorphism had a 2.165-times higher risk of RCC progression than carriers of the GC genotype(Hazard ratio = 2.15, 95% CI, 1.270–3.687).Conclusion The IL-18-137G allele was correlated with more advanced stage, higher tumor grade, and lymph node metastasis. IL-18 gene promoter polymorphism -137G/C may thus influence the prognosis of RCC patients.

关 键 词：INTERLEUKIN-18 renal cell carcinoma POLYMORPHISM PROGNOSIS 

分 类 号：R73[医药卫生—肿瘤]