硫辛酸对蛋鸡早期抗氧化及免疫功能的影响  

Effect of alpha-lipoic acid on antioxidant and immune function in early laying hens

作　　者：崔君 秦蕾 田川尧 李留安 张建斌 CUI Jun;QIN Lei;TIAN Chuanyao;LI Liuan;ZHANG Jianbin(College of Animal Medicine,Jilin University,Changchun,Jilin Province 130062,China;Department of Animal Science and Veterinary Medicine,Tianjin Agricultural University,Tianjin 300384,China)

机构地区：[1]吉林大学动物医学学院,吉林长春130062 [2]天津农学院动物科学与动物医学学院,天津300384

出　　处：《中国饲料》2020年第1期45-48,共4页China Feed

基　　金：天津市“131”创新型人才团队建设项目（20180318）;天津市科技重大专项与工程项目（18ZXBFNC00310）

摘　　要：为研究饲料中添加硫辛酸对蛋鸡开产阶段血液抗氧化及免疫功能的影响,本试验选用22周龄的雪山鸡288只,随机分为3组,每组设6个重复,每个重复16只鸡,分别饲喂不同浓度(0、300、500 mg/kg)的硫辛酸日粮。进行为期6周的饲养试验。结果表明:试验组血清中谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)和免疫球蛋白M含量显著提高(P<0.05),血清总抗氧化能力(T-AOC)、免疫球蛋白G(IgG)和干扰素-γ(INF-γ)含量有升高趋势,但各组间差异不显著(P>0.05),试验2组白细胞介素-2(IL-2)、白细胞介素-4(IL-4)和γ-谷氨酰基转移酶(GGT)含量显著降低(P<0.05),肿瘤坏死因子-α(THF-α)、肌酐(CRE)和尿酸(UA)含量有降低趋势,各组间差异不显著(P>0.05)。由此可见,饲料中添加硫辛酸可以提高动物机体的健康水平。The aim of this study was conducted to investigate the effects of alpha-lipoic acid on the antioxidant and immune function of Xueshan chickens.Two hundred and eighty-eight 22-week-old Xueshan chickens were randomly divided into three groups with 6 replicates per group and 16 chickens per replicate.Chickens in the control group were fed basal diet,and the others in the experimental group 1 and experimental group 2 were fed the basal diet supplemented with 300 mg/kg and 500 mg/kg(mass fraction)of alpha-lipoic acid.The experiment lasted for 6 weeks.The results showed as follows:compared with the control group,experimental group significantly increased the content of glutathione peroxidase,superoxide dismutase and immunoglobulin M of Xueshan chickens(P<0.05);Total antioxidant capacity,immunoglobulin G,interferon-γof serum were increased(P>0.05).The content of interleukin-2,interleukin-4,γ-glutamyltransferase of experimental group 2 were significantly decreased(P<0.05).The content of tumor necrosis factor-alpha,creatinine,uric acid of serum were declined(P>0.05).In summary,adding alpha-lipoic acid was able to efficiently improve the health level of chicken body.

关 键 词：硫辛酸 雪山鸡 抗氧化能力 免疫功能 

分 类 号：S816.7[农业科学—饲料科学]