Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer  

作　　者：Shi-Tong Wang Wen-Qi Cui Dan Pan Min Jiang Bing Chang Li-Xuan Sang 

机构地区：[1]Department of Cardiovascular Ultrasound,First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China [2]Department of Neurology,Shengjing Hospital,Affiliated Hospital of China Medical University,Shenyang 110004,Liaoning Province,China [3]Department of Geriatrics,First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China [4]Department of Gastroenterology,First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China

出　　处：《World Journal of Gastroenterology》2020年第6期562-597,共36页世界胃肠病学杂志（英文版）

基　　金：Supported by the Innovative Talents Support Program of Institution of Higher Learning of Liaoning Province,No.2018-478;Innovative Talents of Science and Technology Support Program of Young and Middle Aged People of Shenyang,No.RC170446

摘　　要：Colorectal cancer(CRC),a multifactorial disease,is usually induced and developed through complex mechanisms,including impact of diet and lifestyle,genomic abnormalities,change of signaling pathways,inflammatory response,oxidation stress,dysbiosis,and so on.As natural polyphenolic phytochemicals that exist primarily in tea,tea polyphenols(TPs)have been shown to have many clinical applications,especially as anticancer agents.Most animal studies and epidemiological studies have demonstrated that TPs can prevent and treat CRC.TPs can inhibit the growth and metastasis of CRC by exerting the antiinflammatory,anti-oxidative or pro-oxidative,and pro-apoptotic effects,which are achieved by modulations at multiple levels.Many experiments have demonstrated that TPs can modulate several signaling pathways in cancer cells,including the mitogen-activated protein kinase pathway,phosphatidylinositol-3 kinase/Akt pathway,Wnt/β-catenin pathway,and 67 kDa laminin receptor pathway,to inhibit proliferation and promote cell apoptosis.In addition,novel studies have also suggested that TPs can prevent the growth and metastasis of CRC by modulating the composition of gut microbiota to improve immune system and decrease inflammatory responses.Molecular pathological epidemiology,a novel multidisciplinary investigation,has made great progress on CRC,and the further molecular pathological epidemiology research should be developed in the field of TPs and CRC.This review summarizes the existing in vitro and in vivo animal and human studies and potential mechanisms to examine the effects of tea polyphenols on CRC.Colorectal cancer(CRC), a multifactorial disease, is usually induced and developed through complex mechanisms, including impact of diet and lifestyle,genomic abnormalities, change of signaling pathways, inflammatory response,oxidation stress, dysbiosis, and so on. As natural polyphenolic phytochemicals that exist primarily in tea, tea polyphenols(TPs) have been shown to have many clinical applications, especially as anticancer agents. Most animal studies and epidemiological studies have demonstrated that TPs can prevent and treat CRC.TPs can inhibit the growth and metastasis of CRC by exerting the anti-inflammatory, anti-oxidative or pro-oxidative, and pro-apoptotic effects, which are achieved by modulations at multiple levels. Many experiments have demonstrated that TPs can modulate several signaling pathways in cancer cells,including the mitogen-activated protein kinase pathway, phosphatidylinositol-3 kinase/Akt pathway, Wnt/β-catenin pathway, and 67 kDa laminin receptor pathway, to inhibit proliferation and promote cell apoptosis. In addition, novel studies have also suggested that TPs can prevent the growth and metastasis of CRC by modulating the composition of gut microbiota to improve immune system and decrease inflammatory responses. Molecular pathological epidemiology, a novel multidisciplinary investigation, has made great progress on CRC, and the further molecular pathological epidemiology research should be developed in the field of TPs and CRC. This review summarizes the existing in vitro and in vivo animal and human studies and potential mechanisms to examine the effects of tea polyphenols on CRC.

关 键 词：Tea polyphenols Colorectal cancer Gut microbiota Signal pathway ANTIINFLAMMATION MECHANISMS 

分 类 号：R735.34[医药卫生—肿瘤]