Eye metastasis in lung adenocarcinoma mimicking anterior scleritis:A case report  

作　　者：Hua-Fei Chen Wen-Xian Wang Xiao-Feng Li Li-Xin Wu You-Cai Zhu Kai-Qi Du Chun-Wei Xu 

机构地区：[1]Thoracic Disease Center,Zhejiang Rongjun Hospital,Jiaxing 314000,Zhejiang Province,China [2]Department of Chemotherapy,Zhejiang Cancer Hospital,Hangzhou 310022,Zhejiang Province,China [3]Department of Pathology,Fujian Cancer Hospital,Fujian Medical University Cancer Hospital,Fuzhou 350014,Fujian Province,China

出　　处：《World Journal of Clinical Cases》2020年第2期410-414,共5页世界临床病例杂志

基　　金：Supported by Science and Technology Planning Project of Zhejiang Province,No.LGF19H160002;Medical Scientific Research Foundation of Zhejiang Province of China,No.2019RC027;Scientific Research Foundation of Zhejiang Medical Association,No.2018ZYC-B5;Technology Bureau of Jiaxing City of Zhejiang Province,No.2017BY18050,No.2018AD32163,and No.2019AD32266;Xisike-Hanson Cancer Research Foundation,No.Y-HS2019-20

摘　　要：BACKGROUND The eye is a rare site for lung cancer metastasis. Indeed, ocular metastasis is one of the greatest challenges to quality of life in a cancer patient. Here we present a patient with lung adenocarcinoma and ocular metastasis.CASE SUMMARY The patient was a 70-year-old man diagnosed with lung adenocarcinoma who developed eye metastasis mimicking anterior scleritis. Brain magnetic resonance imaging showed an abnormal signal in the right eye. Based on next generation sequencing of the surgical specimen, the patient was shown to have a KRAS point mutation(p.G12D).CONCLUSION Multidiscipline expertise collaboration is needed to make the early diagnosis and determine the prompt treatment in patients. We hope to increase the awareness of the possibility of lung cancer metastasizing to the eye.BACKGROUND The eye is a rare site for lung cancer metastasis. Indeed, ocular metastasis is one of the greatest challenges to quality of life in a cancer patient. Here we present a patient with lung adenocarcinoma and ocular metastasis.CASE SUMMARY The patient was a 70-year-old man diagnosed with lung adenocarcinoma who developed eye metastasis mimicking anterior scleritis. Brain magnetic resonance imaging showed an abnormal signal in the right eye. Based on next generation sequencing of the surgical specimen, the patient was shown to have a KRAS point mutation(p.G12D).CONCLUSION Multidiscipline expertise collaboration is needed to make the early diagnosis and determine the prompt treatment in patients. We hope to increase the awareness of the possibility of lung cancer metastasizing to the eye.

关 键 词：Eye METASTASES Non-small cell lung cancer KRAS mutation Case report 

分 类 号：R734.2[医药卫生—肿瘤]