Idarubicin vs doxorubicin in transarterial chemoembolization of intermediate stage hepatocellular carcinoma  

作　　者：Gael Stephane Roth Yann Teyssier Melodie Abousalihac Arnaud Seigneurin Julien Ghelfi Christian Sengel Thomas Decaens 

机构地区：[1]Clinique Universitaire d’Hepato-Gastroenterologie et Oncologie Digestive,CHU Grenoble-Alpes,Grenoble 38043,France [2]Facultede Medicine,Universite Grenoble-Alpes,Domaine de la Merci,La Tronche 38700,France [3]Institute for Advanced Biosciences-INSERM U1209/CNRS UMR 5309/Universite Grenoble-Alpes,Site Santé-Allée des Alpes,La Tronche 38700,France [4]Clinique Universitaire de Radiologie et Imagerie Médicale,CHU Grenoble-Alpes,Grenoble 38043,France [5]Departement de Sante Publique-CHU Grenoble-Alpes,Grenoble 38043,France [6]Department of Hepatology and Gastroenterology,Grenoble-Alpes University Hospital,Grenoble 38043,France

出　　处：《World Journal of Gastroenterology》2020年第3期324-334,共11页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Liver cancer is the fifth most common cancer and the second cause of cancerrelated deaths worldwide.Transarterial chemoembolization(TACE)is the best treatment of intermediate hepatocellular carcinoma(HCC).Doxorubicin is the most commonly used drug despite a low level of evidence.AIM To compare the objective response rate of idarubicin-based TACE(Ida-TACE)against doxorubicin-based TACE(Dox-TACE)in intermediate stage HCC.METHODS Between January 2012 and December 2014,all patients treated with TACE at our academic hospital were screened.Inclusion criteria were patients with Child-Pugh score A or B,a performance status below or equal to 1,and no prior TACE.Either lipiodol TACE or drug-eluting beads TACE could be performed with 10 mg of idarubicin or 50 mg of doxorubicin.Each patient treated with idarubicin was matched with two doxorubicin-treated patients.The TACE response was assessed by independent radiologists according to the mRECIST criteria.RESULTS Sixty patients were treated with doxorubicin and thirty with idarubicin.There were 93%and 87%of cirrhotic patients and 87%and 70%of Child-Pugh A in the doxorubicin and idarubicin groups,respectively.The median number of HCC per patient was two in both groups with 31%and 26%of single nodules in doxorubicin and idarubicin groups,respectively.Objective response rate after first TACE was 76.7%and 73.3%(P=0.797)with 41.7%and 40.0%complete response in doxorubicin and idarubicin groups,respectively.Progression-free survival was 7.7 mo in both groups,and liver transplant-free survival was 24.9 mo and 21.9 mo in doxorubicin and idarubicin groups,respectively.Safety profiles were similar in both groups,with grade 3-4 adverse events in 35%of Dox-TACE and 43%of Ida-TACEs.CONCLUSION Ida-TACE and Dox-TACE showed comparable results in terms of efficacy and safety.Ida-TACE may represent an interesting alternative to Dox-TACE in the management of patients with intermediate stage HCC.BACKGROUND Liver cancer is the fifth most common cancer and the second cause of cancerrelated deaths worldwide.Transarterial chemoembolization(TACE) is the best treatment of intermediate hepatocellular carcinoma(HCC).Doxorubicin is the most commonly used drug despite a low level of evidence.AIM To compare the objective response rate of idarubicin-based TACE(Ida-TACE)against doxorubicin-based TACE(Dox-TACE) in intermediate stage HCC.METHODS Between January 2012 and December 2014,all patients treated with TACE at our academic hospital were screened.Inclusion criteria were patients with ChildPugh score A or B,a performance status below or equal to 1,and no prior TACE.Either lipiodol TACE or drug-eluting beads TACE could be performed with 10 mg of idarubicin or 50 mg of doxorubicin.Each patient treated with idarubicin was matched with two doxorubicin-treated patients.The TACE response was assessed by independent radiologists according to the m RECIST criteria.RESULTS Sixty patients were treated with doxorubicin and thirty with idarubicin.There were 93% and 87% of cirrhotic patients and 87% and 70% of Child-Pugh A in the doxorubicin and idarubicin groups,respectively.The median number of HCC per patient was two in both groups with 31% and 26% of single nodules in doxorubicin and idarubicin groups,respectively.Objective response rate after first TACE was 76.7% and 73.3%(P = 0.797) with 41.7% and 40.0% complete response in doxorubicin and idarubicin groups,respectively.Progression-free survival was 7.7 mo in both groups,and liver transplant-free survival was 24.9 mo and 21.9 mo in doxorubicin and idarubicin groups,respectively.Safety profiles were similar in both groups,with grade 3-4 adverse events in 35% of Dox-TACE and 43% of Ida-TACEs.CONCLUSION Ida-TACE and Dox-TACE showed comparable results in terms of efficacy and safety.Ida-TACE may represent an interesting alternative to Dox-TACE in the management of patients with intermediate stage HCC.

关 键 词：Hepatocellular carcinoma Transarterial chemoembolization IDARUBICIN DOXORUBICIN Intermediate stage 

分 类 号：R73[医药卫生—肿瘤]