人食管下括约肌G蛋白耦联受体的表达及作用机制  

Expression and mechanism of G protein-coupled receptors in human lower esophageal sphincter

作　　者：张珂[1,2] 张聪 高静 王海辰[4] 韩彩娜 张微 刘俊峰[7] Zhang Ke;Zhang Cong;Gao Jing;Wang Haichen;Han Caina;Zang Wei;Liu Junfeng(Department of Thoracic Surgery,Affiliated Hospital of Hebei University,Baoding 071000,China;Basic Research Key Laboratory of General Surgery for Digital Medicine,Baoding 071000,China;Department of Pre-hospital Emergency,The First Center Hospital of Baoding City,Baoding 071000,China;The Third Department of Medical Imaging,The First Center Hospital of Baoding City,Baoding 071000,China;Department of Critical Medicine,The First Center Hospital of Baoding City,Baoding 071000,China;The Third Department of Laboratory Medicine,The First Center Hospital of Baoding City,Baoding 071000,China;Department of Thoracic Surgery,Fourth Hospital,Hebei Medical University,Shijiazhuang 050011,China)

机构地区：[1]河北大学附属医院胸外科,保定071000 [2]河北省普通外科数字医学基础研究重点实验室 [3]保定市第一中心医院院前急救科 [4]保定市第一中心医院院医学影像三科 [5]保定市第一中心医院院重症医学科 [6]保定市第一中心医院院医学检验三科 [7]河北医科大学第四医院胸外科,石家庄050011

出　　处：《中华胸部外科电子杂志》2019年第4期248-252,共5页CHINESE JOURNAL OF THORACIC SURGERY：Electronic Edition

基　　金：国家自然科学基金项目(30371413);河北省重点研发计划项目(18277790D);河北省卫生健康技术研究暨成果转化重点项目(zh2018013)

摘　　要：人食管下括约肌(LES)包括神经调节、自身调节、体液调节三种调节方式。三种方式中体液调节涉及多种激素类物质,但均与G蛋白耦联受体结合发挥作用。激素类物质因配体和受体的不同调节功能也不尽相同。通过研究其作用机制发现通过进一步开发,有望通过药物调节治疗食管动力性疾病。The lower esophageal sphincter(LES)includes three ways of regulation:nerve-regulation,self-regulation and body fluid regulation.Among the three ways,humoral regulation involves a variety of hormones,but all of them play a role in binding with G protein-coupled receptors(GPCRs).Because of the different regulatory functions of ligands and receptors,hormone substances also have different regulatory functions.Through the study of its mechanism,we found that through further research and development,it is expected to treat esophageal motility diseases through drug regulation.

关 键 词：食管下括约肌 神经调节 自身调节 体液调节 G蛋白耦联受体 食管动力性疾病 

分 类 号：R571[医药卫生—消化系统]