Semaphorin 3F在肿瘤中的研究进展  

Research progress of Semaphorin 3F in tumors

作　　者：左志博 郭志琴[1] 王振[1] 杨宏杰[1] 邬万新[1] ZUO Zhibo;GUO Zhiqin;WANG Zhen;YANG Hongjie;WU Wanxin(First Affiliated Hospital of Jiaxing University,Jiaxing 314000,China)

机构地区：[1]嘉兴学院附属第一医院

出　　处：《实用肿瘤学杂志》2020年第1期88-92,共5页Practical Oncology Journal

摘　　要：Semaphorin是一种分泌型或跨膜型蛋白,广泛表达于各器官与组织,作为轴突导向分子在神经系统的发育中发挥作用。越来越多的研究表明Semaphorin还在免疫系统、心血管系统及肿瘤进展方面有着重要影响。Semaphorin 3F是Semaphorin家族中的成员之一,在多种肿瘤中表达缺失。Semaphorin 3F通过与其受体结合激活相关信号通路,参与了调控肿瘤细胞的增殖、分化及转移等过程,其表达水平与肿瘤的发生、发展和预后密切相关。本文就Semaphorin 3F在肿瘤中的研究进展进行综述。Semaphorin is a secreted or transmembrane protein,which is widely expressed in various organs and tissues,and acts as axonal targeting molecule in the development of the nervous system.More and more studies have shown that Semaphorin also has an important impact on the immune system,cardiovascular system and tumor progression.Semaphorin 3F is a members of the semaphorin family and is expressed in a variety of tumors.Semaphorin 3F is involved in the regulation of tumor cell proliferation,differentiation and metastasis by binding to its receptor and activating its related signaling pathways.Its expression level is closely related to tumor occurrence,development and prognosis.This article reviews the research progress of semaphorin 3F in tumors.

关 键 词：SEMAPHORIN 3F 肿瘤 靶向治疗 

分 类 号：R730[医药卫生—肿瘤]