Leonurine: From Gynecologic Medicine to Pleiotropic Agent  

作　　者：LI Yun-yun LIN Yi-kong LIU Xin-hua WANG Li YU Min LI Da-jin ZHU Yi-zhun DU Mei-rong 

机构地区：[1]NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research),Hospital of Obstetrics and Gyn ecology,Fuda n Un iversity Sha nghai Medical College,Shanghai(200011),China [2]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai(200011),China [3]Shanghai Key Laboratory of Bioactive Small Molecules,Department of Pharmacology,School of Pharmacy,Fudan University,Shanghai(201203),China [4]State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy,Macao Un iversity of Science and Tech no logy,Macao SAR,China

出　　处：《Chinese Journal of Integrative Medicine》2020年第2期152-160,共9页中国结合医学杂志（英文版）

摘　　要：Leonurus japonicus Houtt,a Chinese traditional herbal medicine,has been widely used to cure gynecological diseases,such as incomplete abortion and menoxenia.Leonurine,a major active alkaloid compound only be found in Leonurus japonicus Houtt,has been successfully extracted and purified.Recent evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress,inflammation,fibrosis,apoptosis,and multiple metabolic disorders.Here,we have reviewed the pharmacological actions and biological functions of leonurine,with a focus on the role of leonurine in the amelioration of various pathological processes.Insights into the related signaling pathways and molecular mechanisms have strengthened our understanding on the function of leonurine in the alleviation of multiple pathological states.Our summary of the existing researches should help direct future research into the basic science and clinical applications in related diseases.Leonurus japonicus Houtt, a Chinese traditional herbal medicine, has been widely used to cure gynecological diseases, such as incomplete abortion and menoxenia. Leonurine, a major active alkaloid compound only be found in Leonurus japonicus Houtt, has been successfully extracted and purified. Recent evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress, inflammation, fibrosis, apoptosis, and multiple metabolic disorders. Here, we have reviewed the pharmacological actions and biological functions of leonurine, with a focus on the role of leonurine in the amelioration of various pathological processes. Insights into the related signaling pathways and molecular mechanisms have strengthened our understanding on the function of leonurine in the alleviation of multiple pathological states. Our summary of the existing researches should help direct future research into the basic science and clinical applications in related diseases.

关 键 词：LEONURINE Leonurus japonicus Houtt Chinese medicine oxidative stress inflammation FIBROSIS clinical application 

分 类 号：R271.1[医药卫生—中医妇科学]