音乐神经反馈改善大学生阈下抑郁状态研究  

Improving college students sub-threshold depression by music neurofeedback

作　　者：李昕[1,2] 丁欣悦 崔薇 宋鑫旺[1,2] 史春燕 李向东 LI Xin;DING Xinyue;CUI Wei;SONG Xinwang;SHI Chunyan;LI Xiangdong(Institute of Biomedical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,P.R.China;Measurement Technology and Instrumentation Key Lab of Hebei Province,Qinhuangdao,Hebei 066004,P.R.China;HanDan Central Hospital,Handan,Hebei 056000,P.R.China;HUISIANPU Medical Instruments Co.,Ltd.,Qinhuangdao,Hebei 066000,P.R.China)

机构地区：[1]燕山大学生物医学工程研究所,河北秦皇岛066004 [2]河北省测试计量技术及仪器重点试验室,河北秦皇岛066004 [3]邯郸市中心医院,河北邯郸056000 [4]惠斯安普医学系统股份有限公司,河北秦皇岛066000

出　　处：《生物医学工程学杂志》2020年第1期54-60,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目（51677162）;河北省自然科学基金资助项目（F2019203515,F2014203244）;中国博士后科学基金资助项目（2014M550582）

摘　　要：阈下抑郁是指达不到抑郁症诊断标准的以抑郁心境为主的心理亚健康状态,适度干预可以改善其状态,降低病情发展风险。本文针对音乐神经反馈改善大学生阈下抑郁状态展开研究。24名阈下抑郁大学生参与本次试验,其中16名为试验组成员。采用基于频谱分类的解压类音乐对16名试验组成员进行10 min/d,周期为14 d的音乐神经反馈刺激,8名对照组成员不做任何刺激。本文提取并分析受试者脑电信号的相对功率、样本熵、复杂度共3个特征参数。研究结果表明,经音乐神经反馈刺激后,试验组人员的α、β、θ节律相对功率增大,δ节律相对功率减小;样本熵和复杂度均显著提高,且差异具有统计学意义(P<0.05);对照组特征参数差异均无统计学意义。试验组经音乐神经反馈刺激后,抑郁自评量表(SDS)得分减少,表明抑郁情绪得到改善。本研究结果表明,音乐神经反馈刺激可以改善阈下抑郁情绪,今后或可为大学生情绪自我调节提供一种有效的新思路。Sub-threshold depression refers to a psychological sub-health state that fails to meet the diagnostic criteria for depression.Appropriate intervention can improve the state and reduce the risks of disease development.In this paper,we focus on music neurofeedback stimulation improving emotional state of sub-threshold depression college students.Twenty-four college students with sub-threshold depression participated in the experiment,16 of whom were members of the experimental group.Decompression music based on spectrum classification was applied to 16 experimental group participants for 10 min/d music neural feedback stimulation with a period of 14 days,and no stimulation was applied to 8 control group participants.Three feature parameters of electroencephalogram(EEG)relative power,sample entropy and complexity were extracted for analysis.The results showed that the relative power ofα、βandθrhythm increased,whileδrhythm decreased after the stimulation of musical nerofeedback in the experimental group.The sample entropy and complexity were significantly increased after the stimulation,and the differences of these parameters pre and post stimulation were statistically significant(P<0.05),while the differences of all feature parameters in the control group were not statistically significant.In the experimental group,the scores of self-rating depression scale(SDS)decreased after the stimulation of musical nerofeedback,indicating that the depression was improved.The result of this study showed that music neurofeedback stimulation can improve sub-threshold depression and may provides an effective new way for college students to self-regulation of emotion.

关 键 词：阈下抑郁 音乐神经反馈刺激 相对功率 样本熵 复杂度 

分 类 号：R749.4[医药卫生—神经病学与精神病学]