White blood cell count and the incidence of hyperuricemia:insights from a community-based study  

作　　者：Jian Liu Pingyan Shen Xiaobo Ma Xialian Yu Liyan Ni Xu Hao Weiming Wang Nan Chen 

机构地区：[1]Department of Nephrology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Institute of Nephrology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《Frontiers of Medicine》2019年第6期741-746,共6页医学前沿（英文版）

基　　金：This study was supported by the National Project for the Construction of Clinical Key Specialty,Project of Special Fund for Health-Scientific Research(No.201002010);National Key Research and Development Program of China(No.2016YFC 1305402);National Key Technology R&D Program(No.2011BAI10B00);Experimental Animal Project of Shanghai Science and Technology Committee(No.15140902800);Key Projects of National Basic Research Program of China(973 Program,Nos.2012CB517700 and 2012CB517604);National Natural Science Foundation of China(Nos.81700647,81270782,and 30771000);Key Discipline Construction Projects approved by the Health Development Planning Commission of Shanghai.

摘　　要：Hyperuricemia(HUA)is a risk factor for chronic kidney disease(CKD).The relationship between HUA and white blood cell(WBC)count remains unknown.A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014.CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min·1.73 m2).HUA was defined as serum uric acid>420µmol/L in men and>360µmol/L in women.This study included 1024 participants.The prevalence of HUA was 17.77%.Patients with HUA were more likely to have higher levels of WBC count,which was positively associated with HUA prevalence.This association was also observed in participants without CKD,diabetes mellitus,hyperlipidemia,or obesity.Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants.Compared with participants without HUA,inflammatory factors such as high-sensitivity C-reactive protein,tumor necrosis factor-α,and interleukin 6 increased in participants with HUA.Hence,WBC count is positively associated with HUA,and this association is independent of conventional risk factors for CKD.

关 键 词：white blood cell count HYPERURICEMIA chronic kidney disease INFLAMMATION 

分 类 号：R58[医药卫生—内分泌]