Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review  

作　　者：Ran Cheng Zhiwu Wu Mingming Li Meiying Shao Tao Hu 

机构地区：[1]State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu,China [2]West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,China

出　　处：《International Journal of Oral Science》2020年第1期1-9,共9页国际口腔科学杂志（英文版）

基　　金：This research was funded by the National Natural Science Foundation of China (Grant No. 81970948);the Innovation Spark Project of Sichuan University (2018SCUH0054);the Sichuan Provincial Natural Science Foundation of China (2018SZ0139)。

摘　　要：Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.

关 键 词：INTERLEUKIN THERAPEUTIC PERIOD 

分 类 号：R781.42[医药卫生—口腔医学]