Associations between Vaspin Levels and Coronary Artery Disease  

作　　者：Lutfu Askin Okan Tanriverdi Hakan Tibilli Serdar Turkmen 

机构地区：[1]Department of Cardiology,Adiyaman Education and Research Hospital,Adiyaman,Turkey

出　　处：《Cardiovascular Innovations and Applications》2020年第1期211-216,共6页心血管创新与应用（英文）

摘　　要：The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers.Although adipokine concentrations have been shown to be increased signifi cantly in atherosclerotic lesions,the role adipokines in the atherosclerotic process remains to be elucidated.Vaspin is a new biological marker associated with obesity and impaired insulin sensitivity.Plasma vaspin concentration has been shown to correlate with the severity of coronary artery disease.Vascular infl ammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation.Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio.The therapeutic goal concerning vaspin is to fi ght atherosclerosis and related diseases,as well as to maintain vascular health.

关 键 词：ADIPOKINE ATHEROSCLEROSIS infl ammation CORONARY ARTERY disease VASPIN 

分 类 号：R58[医药卫生—内分泌]