深圳福田社区帕金森病前驱期调查及其发病危险因素分析  

Investigation of progenitor period of Parkinson's disease in Futian Community,Shenzhen and the onset risk factors

作　　者：杨长贵[1] 李爱东[2] 蔡思敏[2] 刘翠仪 陈川[2] 郑名烺 Yang Changgui;Li Aidong;Cai Simin;Liu Cuiyi;Chen Chuan;Zheng Minglang(Community Management Center,The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518033,China;Department of Rehabilitation,The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518033,China;Management Center of Community Health Service,Futian District,Shenzhen 518033,China)

机构地区：[1]中山大学附属第八医院社管中心,518033 [2]中山大学附属第八医院康复医学科,518033 [3]深圳市福田区社区健康服务管理中心,518033

出　　处：《国际医药卫生导报》2020年第6期780-784,共5页International Medicine and Health Guidance News

基　　金：深圳市科技创新委员会项目(JCYJ20170307110432752)。

摘　　要：目的通过对深圳福田社区帕金森病(PD)进行前驱期筛查,对PD易患基因进行调查,并分析其危险因素。方法通过国际运动障碍协会(MDS)制定的MDS-PD前驱期筛查软件筛查出深圳福田社区PD前驱期者,共收集40例(为前驱期组),同时收集2016—2019年在福田区属医院诊治的PD患者(为PD组)40例,采用非运动症状问卷(NMSQ)、头颅核磁共振(MRI)检查以及TaqMan法对两组患者进行筛查,统计非运动症状、MRI成像以及检测两组LRRK2基因R1268P、G2385R位点出现频率,采取病例-对照研究方法,探讨非运动症状问卷、MRI以及基因位点筛查与PD发病的关联性。结果与前驱期组相比,PD组非运动症状问卷阳性率高于前驱期组,差异有统计学意义(P<0.05);PD组R1268P等位基因G和C,G2385R等位基因G和A,分布频率差异有统计学意义(P=0.011,P<0.001,P=0.005),R1268P位点突变增加PD患病风险(C与G:OR=1.983;GC+CC与GG:OR=1.971),G2385R携带A等位基因与携带纯合子GG相比患病风险更高(GA+AA与GG:OR=2.4);PD组信号改变大于前驱期组,差异具有统计学意义(P<0.05)。结论非运动症状问卷、MRI以及LRRK2基因R1268P、G2385R位点可能与深圳福田社区PD发病有关,尤其是G2385RA等位基因可能是PD发病的危险因素,可作为PD筛查重要的参考客观依据。Objective To investigate and analyze the risk factors of PD pre-screening Parkinson's disease patients in Futian Community,Shenzhen.Methods The MDS-PD prodromal screening software which was formulated by the International Movement Disorders Association(MDS)was used to screen out the PD progenitors in Futian Community,Shenzhen.A total of 40 patients were collected as a prodromal group;and 40 PD patients treated at the hospitals in Futian between 2016 and 2019 were collected as a PD group.Both groups were screened by non-motor symptoms questionnaire(NMSQ),cranial nuclear magnetic resonance(MRI),and TaqMan.We statistically calculated the non-motor symptoms and MRI imaging,and detected the frequency of the R1268P and G2385R loci of LRRK2 gene in the two groups.We used a case-control study to explore the association of nonmotor symptoms questionnaires,MRI,and genetic locus screening with the onset of PD.Results The positive rate of non-motor symptoms questionnaire in the PD group was higher than that in the prodromal group(P<0.05).For the R1268P allele G and C as well as the G2385R allele G and A in the PD group,the distribution frequency was statistically different(P=0.011,P<0.001,and P=0.005);the R1268P site mutation increased the risk of PD(C and G:OR=1.983;GC+CC and GG:OR=1.971);G2385R carrying the A allele was more risky than carrying homozygous GG(GA+AA and GG:OR=2.4);and the signal change was greater in the PD group than in the prodromal group,with a statistical difference(P<0.05).Conclusion The non-exercise symptom questionnaire,MRI,and LRRK2 gene R1268P and G2385R loci may be related to the pathogenesis of PD in Futian Community,Shenzhen.In particular,the G2385RA allele may be a risk factor for PD,and may serve as an objective basis for PD screening.

关 键 词：帕金森 非运动症状问卷 核磁共振 基因筛查 

分 类 号：R742[医药卫生—神经病学与精神病学]