Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis  

作　　者：Shaorong Chen Zhuna Wu Yumin Ke Pingping Shu Caihong Chen Ruying Lin Qirong Shi 

机构地区：[1]Department of Obstetrics and Gynecology,the Second Affiliated Hospital,Fujian Medical University,Quanzhou 362000,China

出　　处：《Acta Biochimica et Biophysica Sinica》2019年第11期1096-1105,共10页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the Fujian Province Scientific Foundation(Nos.2017J01182 to Q.S.and 2018NO 196 to S.C.).

摘　　要：Wogonoside,a bioactive flavonoid component derived from Scutellaria baicalensis Georgi,has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer,lung cancer,and leukemia cells.However,whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated.In this study,we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer.Firstly,we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis.Mechanistically,wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1,leading to the activation of the Hippo signaling pathway.Taken together,in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer.

关 键 词：ENDOMETRIAL cancer WOGONOSIDE HIPPO SIGNALING endoplasmic reticulum stress RECEIVED 

分 类 号：R73[医药卫生—肿瘤]