2-甲基-3-甲氧基苯甲酰肼衍生物酰腙的合成与活性研究  

Synthesis and Activity of 2-Methyl-3-methoxy Benzohydrazide Derivatives

作　　者：王晓雅 黄婷 孙安霞 WANG Xiao-ya;HUANG Ting;SUN An-xia(School of Chemistry and Chemical Engineering,Ankang University,Ankang 725000,China)

机构地区：[1]安康学院化学化工学院,陕西安康725000

出　　处：《化学试剂》2020年第3期250-253,共4页Chemical Reagents

基　　金：陕西省自然科学基础研究计划项目(S2018-JC-QN-0631);安康学院创新团队引领项目(2019AYQJ10).

摘　　要：酰腙类化合物具有强且广泛的生物活性,在医药及农药领域都有较为深入的研究报道。以合成农药甲氧基虫酰肼杀虫剂的中间体2-甲基-3-甲氧基苯甲酸为原料,经过酯化反应,再和水合肼反应得到酰肼,进一步与芳香醛反应合成出了4种未见文献报道的酰腙化合物。所得化合物抑制小麦赤霉菌、玉米弯胞病菌、马铃薯干腐病菌的活性研究表明:苄亚甲基的苯环上含活化基CH3的酰腙抑菌活性明显低于含吸电子基溴原子的酰腙抑菌活性,并且邻溴苯亚甲基的酰腙抑菌活性明显要强于溴原子处于间位的。Acylhydrazone compounds have strong and extensive biological activities and have been reported in the field of medicine and pesticides.The intermediate of the synthetic pesticide methoxyhydrazine 2-methyl-3-methoxybenzoic acid was used as raw material,and reacted with hydrazine hydrate to form 2-methyl-3-methoxybenzoyl hydrazide,then reacted with methylbenzaldehyde and bromobenzaldehyde to form four new hydrazone compounds.Bacteriostatic activity was investigated that:benzyl methylene containing activation on the benzene ring of bacteriostatic activity was lower than that of the acyl-hydrazone CH3 containing electronic base of bromine atom absorption acylhydrazone,antibacterial activity,and its adjacent bromine benzylidene acyl hydrazone bacteriostatic activity was obviously superior to the bromine atoms in a bit.

关 键 词：甲氧基苯甲酰肼 酰腙 合成 抑菌活性 小麦赤霉菌 玉米弯胞病菌 马铃薯干腐病菌 

分 类 号：O622.65[理学—有机化学]