联合治疗方案对原发性失眠病人睡眠质量、抑郁情绪及睡眠结构指标的影响  

Influence of combined treatment scheme on sleep quality,depression and sleep structure index of patients with primary insomnia

作　　者：谢宇宽 李杨[1] 陈艳琼[1] 李雪英[1] XIE Yukuan;LI Yang;CHEN Yanqiong;LI Xueying(No.3 Psychiatric Ward,Mental Health Center of Zigong City,Zigong,Sichuan 643100,China)

机构地区：[1]自贡市精神卫生中心精神科三病区,四川自贡643100

出　　处：《安徽医药》2020年第4期771-774,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨联合治疗方案对原发性失眠病人睡眠质量、负面情绪及睡眠结构指标的影响。方法选取自贡市精神卫生中心2016年1月至2018年1月收治原发性失眠病人共160例,以随机数字表法分为对照组(80例)和观察组(80例),其中对照组给予唑吡坦+经颅磁刺激(rTMS)假性刺激治疗,观察组给予唑吡坦+rTMS真性刺激;比较两组病人近期疗效,治疗前后匹茨堡睡眠质量指数量表(PSQI)评分、简单自测抑郁量表(PHQ 9)评分、多导睡眠监测指标、睡眠结构指标水平及不良反应发生率。结果观察组病人近期治疗总有效率为96.25%,明显优于对照组的84.21%(P<0.05);对照组治疗后1周、4周及8周PSQI评分分别为(10.92±2.31)分,(8.49±1.92)分,(7.77±1.38)分;观察组治疗后1周、4周及8周PSQI评分分别为(9.38±2.09)分,(7.12±1.60)分,(5.49±1.01)分;对照组治疗后1周、4周及8周PHQ 9评分分别为(5.96±1.02)分,(5.48±0.89)分,(5.08±0.71)分;观察组治疗后1周、4周及8周PHQ 9评分分别为(5.17±0.89)分,(4.73±0.63)分,(3.84±0.40)分;观察组病人治疗后PSQI评分、PHQ 9评分、多导睡眠监测指标及睡眠结构指标水平均显著优于对照组、治疗前(P<0.05);同时两组病人不良反应发生率比较差异无统计学意义(P>0.05)。结论联合治疗方案用于原发性失眠病人治疗可有效提高睡眠质量,减轻抑郁情绪,改善睡眠结构,且安全性值得认可。Objective To investigate the influence of combined treatment scheme on sleep quality,depression and sleep structure index of patients with primary insomnia.Methods A hundred and sixty patients with primary insomnia treated in Mental Health Center of Zigong City during the period from January 2016 to January 2018 were randomly assigned into control group(80 pa tients)and observation group(80 patients)using random number table method.The control group was treated with zolpidem+sham repetitive transcranial magnetic stimulation(rTMS)and the observation group was treated with zolpidem+low frequency rT MS.Comparison was made between the two groups of the short term clinical efficacy,preoperative and postoperative Pittsburgh sleep quality index(PSQI)scores,nine item patient health questionnaire(PHQ 9)score,polysomnography index and sleep structure in dex and the incidence of adverse reactions.Results The short term clinical efficacy(96.25%)of the observation group was signifi cantly higher than that of the control group(84.21%,P<0.05).The PSQI scores of the control group at 1 week,4 weeks and 8 weeks after treatment were(10.92±2.31)points,(8.49±1.92)points,(7.77±1.38)points,respectively;the PSQI scores of the obser vation group at 1 week,4 weeks and 8 weeks after treatment were(9.38±2.09)points,(7.12±1.60)points,(5.49±1.01)points,re spectively.The PHQ 9 scores of the control group at 1 week,4 weeks and 8 weeks after treatment were(5.96±1.02)points,(5.48±0.89)points,(5.08±0.71)points,respectively;the PHQ 9 scores of the observation group at 1 week,4 weeks and 8 weeks after treatment were(5.17±0.89)points,(4.73±0.63)points,(3.84±0.40)points,respectively.The PSQI scores,PHQ 9 scores,polysom nography index level and sleep structure index level of the observation group after treatmentwere significantly higher than those of the control group and those before treatment(P<0.05).There was no significant difference in the incidence of adverse reactions be tween two groups(P>0.05).Conclusion Combined treatment scheme i

关 键 词：入睡和睡眠障碍 经颅磁刺激 唑吡坦 抑郁症 睡眠期 

分 类 号：R740[医药卫生—神经病学与精神病学]