Preoperative gamma-glutamyltransferase to lymphocyte ratio predicts long-term outcomes in intrahepatic cholangiocarcinoma patients following hepatic resection  

作　　者：Jin-Ju Wang Hui Li Jia-Xin Li Lin Xu Hong Wu Yong Zeng 

机构地区：[1]Department of Liver Surgery and Liver Transplantation Center,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [2]Laboratory of Liver Surgery,West China Hospital,Sichuan University,Chengdu 610065,Sichuan Province,China

出　　处：《World Journal of Gastroenterology》2020年第13期1501-1512,共12页世界胃肠病学杂志（英文版）

基　　金：the National Key Technologies RD Program,No.2018YFC1106803;the Natural Science Foundation of China,No.81972747,No.81872004,No.81770615 and No.81672882;the Science and Technology Support Program of Sichuan Province,No.2019YFQ0001 and No.2017SZ0003。

摘　　要：BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a heterogeneous hepatobiliary cancer with limited treatment options.A number of studies have illuminated the relationship between inflammation-based prognostic scores and outcomes in patients with ICC.However,the use of reliable and personalized prognostic algorithms in ICC after resection is pending.AIM To assess the prognostic value of the gamma-glutamyltransferase to lymphocyte ratio(GLR)in ICC patients following curative resection.METHODS ICC patients following curative resection(2009-2017)were divided into two cohorts:The derivation cohort and validation cohort.The derivation cohort was used to explore an optimal cut-off value,and the validation cohort was used to further evaluate the score.Overall survival(OS)and recurrence-free survival(RFS)were analyzed,and predictors of OS and RFS were determined.RESULTS A total of 527 ICC patients were included and randomly divided into the derivation cohort(264 patients)and the validation cohort(263 patients).The two patient cohorts had comparable baseline characteristics.The optimal cut-off value for the GLR was 33.7.Kaplan-Meier curves showed worse OS and RFS in the GLR>33.7 group compared with GLR≤33.7 group in both cohorts.After univariate and multivariate analysis,the results indicated that GLR was an independent prognostic factor of OS[derivation cohort:hazard ratio(HR)=1.620,95%confidence interval(CI):1.066-2.462,P=0.024;validation cohort:HR=1.466,95%CI:1.033-2.142,P=0.048]and RFS[derivation cohort:HR=1.471,95%CI:1.029-2.103,P=0.034;validation cohort:HR=1.480,95%CI:1.057-2.070,P=0.022].CONCLUSION The preoperative GLR is an independent prognostic factor for ICC patients following hepatectomy.A high preoperative GLR is associated with worse OS and RFS.

关 键 词：GAMMA-GLUTAMYLTRANSFERASE LYMPHOCYTE RATIO GAMMA-GLUTAMYLTRANSFERASE to LYMPHOCYTE RATIO INTRAHEPATIC CHOLANGIOCARCINOMA Prognosis Survival analysis 

分 类 号：R735.7[医药卫生—肿瘤]