Expression of MMP-2 and MMP-13 in Bullous Pemphigoid  

作　　者：Haixiang Zhang Xiaoxu Shi Lanying Qin Zishen Zhao Guojun Fu Jun Peng Wenjing Ye 

机构地区：[1]Department of Dermatology,Cangzhou People's Hospital,Cangzhou,Hebei,061000,China

出　　处：《Journal of Clinical and Nursing Research》2020年第1期7-10,共4页临床护理研究（英文）

摘　　要：Objective:To investigate the expression and significance of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-13(MMP-13)in bullous pemphigoid(BP)skin lesions.Methods:Immunohistochemical SP method was used to detect the expression of MMP-2 and MMP-13 in 32 BP skin lesions,and compared with 15 normal skin tissues.Results:The expression of MMP-2 in the case group was significantly increased(38.56±10.06)compared to the normal control group(21.20±5.98);the expression of MMP-13 in the case group was significantly augmented(18.62±5.90)compared to the normal control group(11.47±8.484).The expressions of MMP-2 and MMP-13 in the skin lesions of patients with bullous pemphigoid were statistically different from those of normal people(both P<0.05).Compared with the expression of MMP-2 and MMP-13 in bullous pemphigoid,the expression of MMP-2 and MMP-13 was moderately correlated(correlation coefficient was 0.523).Conclusion:The expression of MMP-2 and MMP-13 is significantly increased in bullous pemphigoid skin lesions,suggesting that they may play an important role in the pathogenesis of BP.There is a certain correlation between the expression of MMP-2 and MMP-13,suggesting that the high expression of MMP-13 may play a role in the mechanism that further leads to the high expression of MMP-2.

关 键 词：MATRIX METALLOPROTEINASE MMP-2 MMP-13 BULLOUS PEMPHIGOID 

分 类 号：R73[医药卫生—肿瘤]