Seven-step total synthesis of α-cyclopiazonic acid  

作　　者：Shibin Shi Kuo Yuan Yanxing Jia 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China

出　　处：《Chinese Chemical Letters》2020年第2期401-403,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21871013);the Drug Innovation Major Project(No.2018ZX09711-001-005-005)。

摘　　要：A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole.Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired [3+2] annulation to form the C/D rings.A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole.Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired [3+2] annulation to form the C/D rings.

关 键 词：INDOLE ALKALOIDS TOTAL synthesis CASCADE CYCLIZATION NATURAL products 

分 类 号：O626[理学—有机化学]