Effect of Dai-Bai-Jie on the proliferation and migration of the A549 cells  

作　　者：Binxin Lin Xinling Lu Nan Li Ning Xu Jin-Ming Lin 

机构地区：[1]Beijing Key Laboratory of Microanalytical Methods and Instrumentation,Department of Chemistry,Tsinghua University,Beijing 100084,China [2]Department of Chemistry,School of Science,Tianjin University,Tianjin 300000,China

出　　处：《Chinese Chemical Letters》2020年第2期476-478,共3页中国化学快报（英文版）

基　　金：supported by the National Key R&D Program of China(No.2017YFC0906800);National Natural Science Foundation of China(Nos.21435002 and 21621003)。

摘　　要：Lung cancer is the most malignant tumor disease with the highest diagnosis and mortality rate in China.The development of therapeutic drugs is the current research focus.Dai-Bai-Jie is a traditional medicine of the Dai nationality,which is commonly used in the treatment of decreasing swelling,alleviating pain and detoxification.Most of the current researches focused on the component analysis of Dai-Bai-Jie,but few researches studied on its antitumor and pharmacological effect.In this study,we incubated A549 cells with different concentrations of Dai-Bai-Jie.The cell proliferation experiment showed that the DaiBai-Jie solution inhibited the proliferation of A549 cells and caused cell apoptosis.In this work,we confirmed that Dai-Bai-Jie had an inhibitory effect on the proliferation and migration of non-small cell lung cancer A549,which may be used as a novel candidate of anti-tumor therapy for lung cancer patients.Lung cancer is the most malignant tumor disease with the highest diagnosis and mortality rate in China.The development of therapeutic drugs is the current research focus.Dai-Bai-Jie is a traditional medicine of the Dai nationality,which is commonly used in the treatment of decreasing swelling,alleviating pain and detoxification.Most of the current researches focused on the component analysis of Dai-Bai-Jie,but few researches studied on its antitumor and pharmacological effect.In this study,we incubated A549 cells with different concentrations of Dai-Bai-Jie.The cell proliferation experiment showed that the DaiBai-Jie solution inhibited the proliferation of A549 cells and caused cell apoptosis.In this work,we confirmed that Dai-Bai-Jie had an inhibitory effect on the proliferation and migration of non-small cell lung cancer A549,which may be used as a novel candidate of anti-tumor therapy for lung cancer patients.

关 键 词："Dai-Bai-Jie" Apoptosis PROLIFERATION MIGRATION ANTINEOPLASTIC agents 

分 类 号：R285[医药卫生—中药学] TQ461[医药卫生—中医学]