ANTINEOPLASTIC

作品数:71被引量:285H指数:11
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相关领域:医药卫生更多>>
相关作者:宋琦李晓明陈绪军刘志苏艾中立更多>>
相关机构:中国人民解放军白求恩国际和平医院武汉大学北京军区总医院华中科技大学更多>>
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相关基金:国家自然科学基金天津市自然科学基金上海市教委科研基金上海市卫生局资助项目更多>>
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Unlocking the potential of Calculus bovis: A breakthrough in liver cancer treatment via Wnt/β-catenin pathway modulation
《World Journal of Gastroenterology》2025年第4期164-168,共5页Farouk Benmediouni 
Liver cancer remains a significant global health challenge,characterized by high incidence and mortality rates.Despite advancements in medical treatments,the prognosis for liver cancer patients remains poor,highlighti...
关键词:Calculus bovis Liver cancer M2 phenotype tumor-associated macrophages Wnt/β-catenin pathway Traditional Chinese medicine Tumor microenvironment Antineoplastic therapy 
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer
《Acta Pharmaceutica Sinica B》2024年第12期5321-5340,共20页Rong Fu Zhangfeng Dou Ning Li Xueyuan Fan Sajid Amin Jinqi Zhang Yuqing Wang Zongwei Li Zhuoyu Li Peng Yang 
supported by the National Natural Science Foundation of China(Nos.32200321,82270217,31800657,32072220);National Natural Science Foundation of China Regional Innovation and Development Joint Fund Key Support Project(U23A20526,China);Natural Science Foundation of Shanxi Province(Nos.20210302124252,and 202203021211293,China),Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(2021L212,China);“1331 Project”Key Innovation Team of Shanxi Province(Prof.Zhuoyu Li).
Chemoresistance to 5-fluorouracil(5-FU)is a significant challenge in treating colorectal can-cer(CRC).Novel combined regimens to thwart chemoresistance are therefore urgently needed.Herein,we demonstrated that the com...
关键词:Avenanthramide A 5-FLUOROURACIL KDM4C Colorectal cancer MIR17HG 
Complications and comorbidities associated with antineoplastic chemotherapy:Rethinking drug design and delivery for anticancer therapy
《Acta Pharmaceutica Sinica B》2024年第7期2901-2926,共26页Xiaoman Mao Shuang Wu Dandan Huang Chong Li 
supported by the National Natural Science Foundation of China(NSFC No.82373808);Chongqing Science Fund for Distinguished Young Scholars(CSTB2023NSCQ-JQX0021,China);Fundamental Research Funds for the Central Universities(SWURC2020001,China);the project for Chongqing University Innovation Research Group,Chongqing Education Committee(CXQT200006,China).
Despite the considerable advancements in chemotherapy as a cornerstone modality in cancer treatment,the prevalence of complications and pre-existing diseases is on the rise among cancer patients along with prolonged s...
关键词:COMPLICATIONS COMORBIDITIES CHEMOTHERAPY Preclinical cancer models Drug design Drug delivery 
Biochemical hallmarks-targeting antineoplastic nanotherapeutics
《Bioactive Materials》2024年第6期427-454,共28页Jing Han He Dong Tianyi Zhu Qi Wei Yongheng Wang Yun Wang Yu Lv Haoran Mu Shandeng Huang Ke Zeng Jing Xu Jianxun Ding 
supported by the National Key R&D Program of China(Grant No.2021YFC2400600/2021YFC2400605);the National Natural Science Foundation of China(Grant Nos.U23A20591,52273158,82203131,and 81972517);the Shanghai Rising-Star Program(Grant No.22YF1435800 and 20QA1408000);the Science and Technology Development Program of Jilin Province(Grant No.20240101002JJ).
Tumor microenvironments(TMEs)have received increasing attention in recent years as they play pivotal roles in tumorigenesis,progression,metastases,and resistance to the traditional modalities of cancer therapy like ch...
关键词:NANOPARTICLE Biochemical hallmark Tumor microenvironment Controlled drug delivery Cancer therapy 
Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria
《World Journal of Gastrointestinal Oncology》2024年第3期968-978,共11页Ying-Qiao Zhang Qing-Hao Liu Lu Liu Peng-Yu Guo Run-Ze Wang Zhi-Chang Ba 
BACKGROUND Traditional treatments for pancreatic cancer(PC)are inadequate.Photodynamic therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including PC.However,the mitochondrial concentration of the photo...
关键词:Photodynamic therapy Pancreatic cancer VERTEPORFIN MITOCHONDRIA CHEMOTHERAPY GEMCITABINE 
抗肿瘤生物类似药临床互换用药有效性与安全性的系统评价被引量:2
《中国卫生资源》2022年第6期695-700,709,共7页胡杨 宋再伟 姜丹 赵荣生 
国家自然科学基金(72074005)。
目的系统评价抗肿瘤生物类似药临床互换用药的有效性、安全性与免疫原性,为促进其临床合理应用提供循证医学证据。方法系统检索PubMed、Embase、Cochrane Library、中国知网(CNKI)、万方数据库(WANFANG)、中国生物医学文献数据库(SinoM...
关键词:生物类似药biosimilar 抗肿瘤antineoplastic 互换用药switching 可互换性interchangeability 有效性efficacy 安全性safety 免疫原性immunogenicity 
Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway被引量:4
《World Journal of Gastroenterology》2020年第47期7497-7512,共16页Meng-Li Gu Xin-Xin Zhou Meng-Ting Ren Ke-Da Shi Mo-Sang Yu Wen-Rui Jiao Ya-Mei Wang Wei-Xiang Zhong Feng Ji 
Supported by The Traditional Chinese Medicine Science and Technology Plan of Zhejiang Province,No.2017ZZ010;Zhejiang Medical Science and Technology Program,No.2018266817.
BACKGROUND Gastric cancer(GC)is one of the most common and deadliest types of cancer worldwide due to its delayed diagnosis and high metastatic frequency,but its exact pathogenesis has not been fully elucidated.ETS ho...
关键词:Gastric cancer ETS homologous factor C-MET Antineoplastic target Signaling pathway 
Acquired aplastic anemia:Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells?被引量:1
《World Journal of Stem Cells》2020年第11期1429-1438,共10页Xi-Chen Zhao Xiao-Yun Sun Bo Ju Fan-Jun Meng Hong-Guo Zhao 
We previously reported a serendipitous finding from a patient with refractory severe aplastic anemia who had gotten an unexpected hematological response to treatment with gut-cleansing preparations(GCPs).This patient ...
关键词:Acquired aplastic anemia Bystander insult Malignant clonal hematopoiesis Immune surveillance ANTINEOPLASTIC Gut inflammation 
Antineoplastic Drug Handling:Higher Risk for Healthcare Workers in Tunisia than in France?
《Biomedical and Environmental Sciences》2020年第10期803-806,共4页Kaouther Zribi Laetitia Minh Mai Le Asok Rajkumar Hail Aboudagga Mounir Frikha Amandine Dietrich Emna Zribi Fathi Safta Eric Caudron 
part of a cooperative project between French and Tunisian hospitals financed by the French Ministry of Health。
In 2018,the World Health Organization(WHO)reported 9.6 million cancer deaths worldwide,in accordance with the data collected by the International Agency for Research on Cancer(IARC).The fight against cancer and other ...
关键词:CANCER CANCER DISEASES 
Effect of Dai-Bai-Jie on the proliferation and migration of the A549 cells被引量:1
《Chinese Chemical Letters》2020年第2期476-478,共3页Binxin Lin Xinling Lu Nan Li Ning Xu Jin-Ming Lin 
supported by the National Key R&D Program of China(No.2017YFC0906800);National Natural Science Foundation of China(Nos.21435002 and 21621003)。
Lung cancer is the most malignant tumor disease with the highest diagnosis and mortality rate in China.The development of therapeutic drugs is the current research focus.Dai-Bai-Jie is a traditional medicine of the Da...
关键词:"Dai-Bai-Jie" Apoptosis PROLIFERATION MIGRATION ANTINEOPLASTIC agents 
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