Physical activity and risk of age-related cataract  

作　　者：Hong Jiang Li-Na Wang Yan Liu Ming Li Min Wu Yue Yin Le Ma Chang-Rui Wu 

机构地区：[1]First Affiliated Hospital,Xi'an Jiaotong University College of Medicine,Xi'an 710061,Shaanxi Province,China [2]School of Public Health,Xi'an Jiaotong University Health Science Center,Xi'an 710061,Shaanxi Province,China [3]Centre for Population Health Research,Division of Health Sciences,University of South Australia,Adelaide,SA 5001,Australia

出　　处：《International Journal of Ophthalmology(English edition)》2020年第4期643-649,共7页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81473059);the Natural Science Foundation of Shaanxi Province of China(No.2017JM8041);the China Postdoctoral Science Special Foundation(No.2015T81036)。

摘　　要：AIM: To summarize quantitatively the prospective association between physical activity and age-related cataract(ARC) risk.METHODS: Pub Med, Embase, Web of Science, and Cochrane Library were systematically searched for all relevant follow up studies until July 2019. Multivariableadjusted relative risks(RRs) and corresponding 95% confidence intervals(CIs) from individual studies were used to calculate the overall summary estimates. The doseresponse relationship was assessed using generalized least-squares trend estimation.RESULTS: Six prospective cohort studies, involving 19 173 cases in 6.2-12.1 y follow up of 171 620 participants, were included in the analysis. Increased physical activity was significantly associated with reduced risk of ARC by 10%(RR: 0.90;95%CI: 0.81, 0.99, P=0.04). Stratified analysis by assessment method for physical activity suggest that studies using metabolic equivalent(MET) per day tended to report a slightly stronger association with ARC(RR: 0.85;95%CI: 0.81, 0.90, P<0.001) than studies which assessed activity by weekly activity(RR: 0.96;95%CI: 0.89, 1.03, P=0.24). Dose-response analysis indicated that the risk of ARC decreased by 2%(RR: 0.98;95%CI: 0.98, 0.99, P<0.001) for every 6 METs per day increase in activity.CONCLUSION: The findings from this Meta-analysis provide additional evidence that increased physical activity is inversely associated with ARC risk dose-responsively.

关 键 词：PHYSICAL activity AGE-RELATED CATARACT LENS META-ANALYSIS 

分 类 号：R776.1[医药卫生—眼科]