Dermic-derived fibroblasts for the study of amyotrophic lateral sclerosis  

作　　者：Javier Riancho Sara Arozamena Adolfo Lopez de Munain 

机构地区：[1]Service of Neurology,Hospital Sierrallana-IDIVAL,Torrelavega,Spain [2]Department of Medicine and Psychiatry,University of Cantabria,Santander,Spain [3]Centro de Investigacion en Red de Enfermedades Neurodegenerativas,Instituto Carlos III,Madrid,Spain [4]Neurosciences Area,Biodonostia Research Institute,Service of Neurology,Hospital Universitario Donostia,Department of Neurosciences,School of Medicine and Nursery,University of the Basque Country,San Sebastian,Spain

出　　处：《Neural Regeneration Research》2020年第11期2043-2044,共2页中国神经再生研究（英文版）

摘　　要：Among neurodegenerative diseases,amyotrophic lateral sclerosis(ALS)is the most frequent one involving motor neurons(MNs).ALS incidence varies throughout the world ranging from 0.7 to 4 cases per 100,000 habitants and year(Riancho et al.,2016).This disease,which currently lacks an effective therapy,is characterized by a variable combination of upper and lower MN degeneration,leading to progressive muscle wasting which usually results in a terminal respiratory failure within 3 years after symptom onset(Zufiria et al.,2016).A small proportion of ALS cases show familial aggregation.These are related to mutations in specific causative genes(Cr9ORF72,TARDBP,FUS,SOD1 and others)which directly determine disease onset in carriers.By contrast,more than 90 percent of cases are considered to be sporadic,in which generally unknown environmental and internal factors interact with genetic predisposing factors finally leading to disease(Riancho et al.,2018).From a histopathological point of view,ALS is characterized by MN damage and loss.MNs from ALS sporadic and most of familial patients exhibit prominent transactive response DNA-binding protein 43(TDP-43)cytoplasmic aggregates which are considered as the“pathological hallmark”of the disease,excepting those related to SOD1 and FUS mutations(Zufiria et al.,2016).TDP-43 is a DNA/RNA binding protein encoded by the TARDBP gene that controls the expression of many different genes.

关 键 词：al. amyotrophic DEGENERATION 

分 类 号：R744.8[医药卫生—神经病学与精神病学]