多种样品前处理方法在高分辨质谱法检测农药残留中的应用  

Application of various sample pretreatment methods in the detection of pesticide residues by high resolution mass spectrometry

作　　者：刘佳铭 李雯婷[2] 潘惠勤 苗水[2] 季申[2] LIU Jia-Ming;LI Wen-Ting;PAN Hui-Qin;MIAO Shui;JI Shen(China State Institute of Pharmaceutical Industry,Shanghai 201203,China;NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine,Shanghai Institute for Food and Drug Control,Shanghai 201203,China;Shanghai Pharmaceutical Industry Research Institute,Shanghai 201203,China)

机构地区：[1]中国医药工业研究总院,上海201203 [2]上海市食品药品检验所,国家药品监督管理局中药质量控制重点实验室,上海201203 [3]上海医药工业研究院,上海201203

出　　处：《食品安全质量检测学报》2020年第2期433-442,共10页Journal of Food Safety and Quality

基　　金：2017科技部重点研发专项(2017YFC1700800);上海市中药和保健食品品种与安全检测专业技术服务平台(18DZ2292200);上海市科委技术标准专项(18DZ2200900)。

摘　　要：食品、药品中的农药残留安全问题引起社会越来越多的关注,农药残留检测方法为食品、药品安全监管提供技术支撑。高分辨质谱法由于具有较高的分辨率和质量精确度,近年来在农药残留检测中的应用越来越多,尽管高分辨质谱法能在一定程度上降低基质干扰,但样品前处理仍然是必要的。样品前处理可以减少基质干扰成分,提取、富集目标检测物,对农药残留检测方法的准确度、灵敏度和重现性具有重要影响。本文对近年来高分辨质谱法检测农药残留所应用的前处理方法进行概述,主要包括QuEChERS法、固相萃取法、极性农药快速提取法、在线前处理法等,介绍了各前处理方法的原理和应用现状,对不同前处理方法的优缺点进行分析,并对高分辨质谱法检测农药残留所应用的样品前处理的发展趋势进行展望。The safety problem of food and drug caused by pesticide residues has attracted more and more attention of the society.Pesticide residue detection methods provide technical support for food and drug safety supervision.High resolution mass spectrometry(HRMS)has been more and more applied in the detection of pesticide residues in recent years due to its high resolution and quality accuracy.Although HRMS can reduce matrix interference to a certain extent,sample pretreatment is still necessary.Sample pretreatment can reduce matrix interference as well as extract and enrich analytes,which has important influence on the accuracy,sensitivity and reproducibility of pesticide residue detection methods.This paper reviewed the pretreatment methods used in the detection of pesticide residues by HRMS in recent years,mainly including QuEChERS,solid phase extraction(SPE),quick polar pesticides extraction(QuPPe),on-line pretreatment and so on.This article also introduced the principle and application of each pretreatment method,analyzed the advantages and disadvantages of different pretreatment methods,and prospected the development trend of sample pretreatment in pesticide residue detection by HRMS.

关 键 词：农药残留 样品前处理 高分辨质谱法 QUECHERS 固相萃取 在线前处理 

分 类 号：O657.63[理学—分析化学] TS207.53[理学—化学] TQ460.72[轻工技术与工程—食品科学]