关于肿瘤Wnt信号通路棕榈酰化的综述  

作　　者：姜风琳 丁明 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009

出　　处：《科技创新与应用》2020年第13期17-19,共3页Technology Innovation and Application

摘　　要：Wnt信号通路是一条进化上保守的信号通路,可以调节胚胎形成和组织发育等一系列生命过程。WNT蛋白可通过棕榈酰化进行翻译后修饰,对调节WNT蛋白在细胞中的分泌、定位、生物活性和从产生细胞中扩散起着关键作用。Wnt信号调控失衡与人类癌症的发生密切相关,但具体的机制仍不清楚。文章将从Wnt信号途径转导的分子机制、porcupine(Porcn)介导的WNT蛋白的棕榈酰化以及Wnt信号通路在肿瘤中的功能进行探讨。Wnt signal pathway is an evolutionarily conserved signal pathway,which can regulate a series of life processes such as embryonic formation and tissue development.WNT protein can be post-translational modified by palmitoylation,which plays a key role in regulating the secretion,localization,biological activity and diffusion of WNT protein in cells.The imbalance of Wnt signal regulation is closely related to the occurrence of human cancer,but the specific mechanism is still unclear.In this paper,we will discuss the molecular mechanism of Wnt signal transduction,the palmitoylation of WNT protein mediated by porcupine(Porcn)and the function of Wnt signal pathway in tumor.

关 键 词：WNT信号通路 棕榈酰化 PORCUPINE 肿瘤 

分 类 号：R73[医药卫生—肿瘤]