PORCUPINE

作品数：15被引量：4H指数：1
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相关机构：苏州大学成都理工大学南京明德新药研发有限公司贵州大学更多>>
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Ensemble of Deep Learning with Crested Porcupine Optimizer Based Autism Spectrum Disorder Detection Using Facial Images
《Computers, Materials & Continua》2025年第5期2793-2807,共15页Jagadesh Balasubramani Surendran Rajendran Mohammad Zakariah Abeer Alnuaim 
Researchers supporting Project number(RSPD2025R1107),King Saud University,Riyadh,Saudi Arabia.
Autism spectrum disorder(ASD)is a multifaceted neurological developmental condition that manifests in several ways.Nearly all autistic children remain undiagnosed before the age of three.Developmental problems affecti...
关键词：Autism spectrum disorder ensemble learning crested porcupine optimizer facial images computeraided diagnosis 
Exceptionally strong and ductile bulk metallic glass composite with bioinspired architecture mimicking porcupine fish spine
《Journal of Materials Science & Technology》2024年第28期22-28,共7页Xiangcheng Cui Qianyu Jiao Weiqi Wang Long Zhang Yunzhuo Lu 
supported by the National Key Research and Development Program of China under Grant No.2023YFB3408101;the National Natural Science Foundation of China under Grant Nos.52171164 and 52271022;the Youth Innovation Promotion Association CAS(No.2021188).
Introducing soft crystalline phases into the glassy matrix to produce bulk metallic glass composites(BMGCs)is an effective way to enhance the ductility of bulk metallic glasses(BMGs).However,the introduction of soft c...
关键词：Bulk metallic glass composite Bioinspired structure Strength Ductility 
Study of Impact Resistance Based on Porcupine Quills Bionic Thin-walled Structure被引量：1
《Journal of Bionic Engineering》2023年第5期1942-1955,共14页Tianshu Huang Zhengyu Mao Lijun Chang Xingyuan Huang Zhihua Cai 
supported by the National Natural Science Foundation of China(No.11972158);the Postgraduate Scientific Research Innovation Project of Hunan Province(No.CX20221044);the Military Commission Science and Technology Committee Basic Strengthening Program Technology Fund(No.2020-JCJQ-JJ-356)and(No.2019-JCJQ-JJ-150).
Using an electron microscope to observe the microstructure of a porcupine quills cross-section and a bionic method,a new bionic structure was proposed.The performance of the structure in terms of energy absorption,max...
关键词：Bionic structure design Thin-walled structure Impact resistance Specific energy absorption Multi-objective optimization 
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling被引量：2
《Acta Pharmacologica Sinica》2023年第6期1149-1160,共12页Hao Wu Lu-xun Tang Xue-mei Wang Liang-peng Li Xiao-kang Chen Yan-ji He De-zhong Yang Yu Shi Jia-ling Shou Zong-shu Zhang Liang Wang Bing-jun Lu Songzhu Michael An Chun-yu Zeng Wei Eric Wang 
supported by grants from the National Natural Science Foundation of China(81922005,U20A20344);National Key Research&Development Program of China(2018YFA0107403);Chongqing Natural Science Foundation(cstc2020jcyj-jqX0016).
Heart failure with preserved ejection fraction(HFpEF)is highly prevalent,and lacks effective treatment.The aberration of WNT pathway underlies many pathological processes including cardiac fibrosis and hypertrophy,whi...
关键词：heart failure with preserved ejection fraction(HFpEF) cardiac hypertrophy cardiac fibrosis WNT signaling pathway porcupine inhibitor CGX1321 
O-长链脂肪酸修饰在Wnt功能调控中的作用
《生命科学》2020年第12期1304-1314,共11页韩笑 杨飞 刘华东 
国家自然科学基金项目(31670781);中央高校基本科研业务费专项资金资助(zrzd2017010)。
脂酰化是重要的蛋白质翻译后修饰之一。Wnt蛋白是重要的O-脂酰化修饰底物,几乎涉及胚胎发育的各个方面,并控制许多成年组织的自我更新。O-脂酰化修饰影响Wnt的成熟、分泌和活性,该修饰相关基因的突变可导致多种疾病的发生。该文将围绕着...
关键词：WNT O-脂酰化 翻译后修饰 PORCN(Porcupine) 信号转导 
关于肿瘤Wnt信号通路棕榈酰化的综述
《科技创新与应用》2020年第13期17-19,共3页姜风琳 丁明 
Wnt信号通路是一条进化上保守的信号通路,可以调节胚胎形成和组织发育等一系列生命过程。WNT蛋白可通过棕榈酰化进行翻译后修饰,对调节WNT蛋白在细胞中的分泌、定位、生物活性和从产生细胞中扩散起着关键作用。Wnt信号调控失衡与人类癌...
关键词：WNT信号通路 棕榈酰化 PORCUPINE 肿瘤 
LGK974的合成工艺研究
《合成化学》2020年第5期446-450,共5页骆荣双 黄朋越 刘春江 赵庆平 周志旭 黄筑艳 
贵州省科技计划项目(黔科合LH字[2016]7442号,黔科合平台人才[2018]5781号)。
LGK974是一种高度特异性和有效的Porcupine抑制剂。设计了一条新的合成路线,以2-氨基-5-溴吡啶、2-氯-3-甲基吡啶、2-氨基吡嗪和2-甲基-6-氯吡啶为起始原料,采用汇聚法,经取代、Suzuki、酰胺化等10步反应合成了LGK974,总收率11.5%,其结...
关键词：LGK974 Porcupine抑制剂 合成 工艺优化 SUZUKI反应 酰胺化 
在肿瘤类器官中研究Wnt信号通路为靶点的肿瘤治疗新进展
《湖南中医药大学学报》2018年第A01期1136-1136,共1页李风伟 梁红 
类器官是指源于人体的干细胞通过体外3D培养能以与体内相似的方式来增殖和分化,形成保留原器官组织结构和生物信息的“微组织”。利用肿瘤类器官可以来研究肿瘤的演变过程,评估抗肿瘤药物的效果,探究肿瘤的转移机制,而结直肠癌肿瘤类器...
关键词：肿瘤类器官 WNT信号通路 Porcupine蛋白小分子抑制剂 治疗新进展 
Analysis and Evaluation of Nutrient Composition in Different Tissues of the Wild Spot-fin Porcupine Fish(Diodon hystrix)
《Agricultural Science & Technology》2017年第12期2468-2476,共9页yan chen hai huang jun ma liuling gao pan chen 
Supported by Major Science and Technology Projects from Science and Technology Department of Hainan Province,China(ZDKJ2016009;ZDKJ2016013);Natural Science Foundation of Hainan Province(20163074);Key laboratory of Seawater Aquaculture Research of Sanya City(L1507)
Nutrient compositions including proximate, fatty acids, amino acids, minerals and vitamins in tissues of the wild spot-fin porcupinefish(Diodon hystrix) were analyzed in detail to assess their nutrient value and to fu...
关键词：Diodon hystri~  Proximate analysis Fatty acids Amino acid The South China Sea 
God Is a Porcupine—Brain, Consciousness and Spacetime Physics
《Journal of Modern Physics》2017年第8期1294-1318,共25页Walter J. Christensen Jr. 
Whereas the human body requires a vast numbers of atoms to maintain its intricate anatomical functions, we assert that the human brain requires “something extra” to carry out its higher mental and emotional function...
关键词：Neuroscience CONSCIOUSNESS Memory BRAIN Communication SPACETIME SPACETIME Quanta GRAVITONS Time Quanta General Relativity Relativized Quantum PHYSICS (RQP) 
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