Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats  

作　　者：LI Xin-Gang NI Jian SHEN Su WANG Xiao-Ping TIAN Jing-Chen 

机构地区：[1]Department of Pharmacy,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China [2]School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China [3]Department of Pharmacy,Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xian 710003,China [4]Department of Pharmacy,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China

出　　处：《Chinese Journal of Natural Medicines》2020年第3期234-240,共7页中国天然药物（英文版）

摘　　要：Azithromycin and Chinese medicine forsythia are often used together to treat pediatric mycoplasma infections in China. We aimed to investigate the pharmacokinetic interaction of Forsythia suspensa extract and azithromycin after single and co-intravenous administration in rats. Male Sprague-Dawley rats received single(Forsythia suspensa extract or azithromycin) treatment or co-administration of Forsythia suspensa extract and azithromycin. Blood samples were collected at scheduled times, and drug concentrations were determined by HPLC-UV or HPLC-MS/MS methods. Both non-compartmental analyses and nonlinear mixed-effects modeling approaches were applied to fit pharmacokinetic data and evaluate the impact of co-administration. Pharmacokinetic analysis showed that the area under the curve of azithromycin and forsythiaside increased, and clearance decreased significantly(P < 0.05),after co-administration. The in vivo behavior of both azithromycin and forsythiaside could be appropriately described by the two-compartmental model. The final population pharmacokinetic model indicated that co-administration decreased the central volume of azithromycin and forsythiaside clearance significantly. Co-administration of Forsythia suspensa extract and azithromycin significantly decreased the clearance and increased exposure for both drugs. Pharmacokinetic data suggest that drug co-administration may increase efficiency.

关 键 词：FORSYTHIA suspensa AZITHROMYCIN FORSYTHIASIDE CO-ADMINISTRATION Non-compartmental analysis Population pharmacokinetics PHARMACOKINETIC interaction 

分 类 号：R917[医药卫生—药物分析学]