Thirdhand smoke: Genotoxicity and carcinogenic potential  

作　　者：Hang Bo Wang Pin Zhao Yue Chang Hang Mao Jian-Hua Antoine MSnijders 

机构地区：[1]Biological Systems and Engineering Division,Lawrence Berkeley National Laboratory,Berkeley,CA 94720,USA [2]Department of Gastroenterology,Nanjing Drum Tower Hospital,Nanjing University Medical School,Nanjing,Jiangsu 210008,China [3]Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China

出　　处：《Chronic Diseases and Translational Medicine》2020年第1期27-34,共8页慢性疾病与转化医学（英文版）

基　　金：supported by the University of California Tobacco-Related Disease Research Program(TRDRP)research project grants 24RT-0038(BH and JHM)and 28PT-0076(BH,JHM and AMS).

摘　　要：Thirdhand smoke (THS), the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents a hidden and underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Exposure to secondhand smoke (SHS), a precursor of THS, has been well documented as a risk factor for human cancers, especially lung cancer. However, the concept of THS as a distinct entity that poses health risks for small children has developed only recently and the associations of THS with cancer risk and other chronic diseases are poorly understood due to limited numbers of studies to date. In this perspective, we mainly summarize all published studies on the genotoxicity and carcinogenic potential of THS exposure. These studies begin to fill the knowledge gap in our understanding of cancer risk of THS. Accumulating data from existing and future studies will help reduce the tobacco-related cancer incidence through changes in lifestyle and tobacco control policies.

关 键 词：TOBACCO Thirdhand SMOKE Tobacco-specific NITROSAMINES GENOTOXICITY CARCINOGENESIS 

分 类 号：R163[医药卫生—公共卫生与预防医学]