Current advances in haploid stem cells  

作　　者：Tongtong Cui Zhikun Li Qi Zhou Wei Li 

机构地区：[1]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Protein & Cell》2020年第1期23-33,共11页蛋白质与细胞（英文版）

基　　金：supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA16030400);the National Basic Research Program of China(Grant No.2014CB964800);the National Natural Science Foundation of China(Grant Nos.31621004,31422038);the National Key Research and Development Program(Grant No.2017YFA0103803);CAS Key Projects(Grant No.QYZDY-SSWSMC022,QYZDB-SSW-SMC002).

摘　　要：Diploidy is the typical genomic mode in all mammals.Haploid stem cells are artificial cell lines experimentally derived in vitro in the form of different types of stem cells,which combine the characteristics of haploidy with a broad developmental potential and open the possibility to uncover biological mysteries at a genomic scale.To date,a multitude of haploid stem cell types from mouse,rat,monkey and humans have been derived,as more are in development.They have been applied in high-throughput genetic screens and mammalian assisted reproduction.Here,we review the generation,unique properties and broad applications of these remarkable cells.

关 键 词：HAPLOIDY PARTHENOGENETIC ANDROGENETIC stem cells DIPLOIDIZATION functional genomics IMPRINTING 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]