白细胞介素-17C对溃疡性结肠炎的诊断价值  

Diagnostic value of interleukin-17C in ulcerative colitis

作　　者：刘栋[1,2] 何恒[3] 戴军[4] 姚潇颖[5] 司传平 Liu Dong;He Heng;Dai Jun;Yao Xiaoying;Si Chuanping(Department of Immunology,Basic Medicine College,Qingdao University,Qingdao 266071,Shandong,China;Clinical Laboratory,Affiliated Hospital of Jining Medical College,Jining 272029,Shandong,China;Department of Gastroenterology,Affiliated Hospital of Jining Medical College,Jining 272029,Shandong,China;Institute of Immunology and Molecular Medicine,Jining Medical College,Jining 272067,Shandong,China;Institute of Immunoprecision Diagnosis and Transformation Medicine,Affiliated Hospital of Jining Medical College,Jining 272029,Shandong,China)

机构地区：[1]青岛大学基础医学院免疫学系,山东青岛266071 [2]济宁医学院附属医院检验科,山东济宁272029 [3]济宁医学院附属医院消化内科,山东济宁272029 [4]济宁医学院免疫学与分子医学研究所,山东济宁272067 [5]济宁医学院附属医院免疫精准诊疗与转化医学研究所,山东济宁272029

出　　处：《实用检验医师杂志》2020年第1期47-50,共4页Chinese Journal of Clinical Pathologist

基　　金：济宁医学院教师扶持基金(JYFC2019FKJ028)。

摘　　要：目的探讨血清白细胞介素-17C(IL-17C)在溃疡性结肠炎(UC)患者中表达的意义以及体外诊断价值。方法选择2017年12月-2018年6月就诊于济宁医学院附属医院的32例UC患者为UC组,另外选择50例正常健康体检者为健康对照组。收集两组的一般资料,包括性别、年龄、疾病严重程度等,采用酶联免疫吸附试验(ELISA)测定两组的血清IL-17C水平。根据UC病情严重程度不同将UC组分为轻度、中度、重度UC组,根据年龄不同将两组分为<40岁、40~60岁、>60岁组,比较不同分组的IL-17C水平。结果 UC组IL-17C水平明显高于健康对照组(ng/L:251.72±90.49比138.30±68.10),差异有统计学意义(P<0.05)。不同严重程度UC患者的IL-17C水平比较差异无统计学意义(P>0.05),健康对照组IL-17C水平随年龄增长呈上升趋势(P<0.05),UC组各年龄段IL-17C水平比较差异均无统计学意义(均P>0.05)。健康对照组和UC组内不同性别之间的IL-17C水平比较差异均无统计学意义(均P>0.05)。结论血清IL-17C可能在UC的发生发展过程中发挥作用,对诊断UC具有一定的临床价值,有利于UC的体外诊断。Objective To investigate the significance of serum interleukin-17C (IL-17C) expression in patients with ulcerative colitis (UC) and its diagnostic value in vitro.Methods The 32 UC patients in Affiliated Hospital of Jining Medical College during December,2017 to June,2018 were selected as UC group,and 50 normal healthy subjects were selected as control group.The gender,age,disease severity,etc.of two groups were collected,and serum IL-17C in two groups was determined by enzyme-linked immunosorbent assay (ELISA).According to UC degree,UC group was divided into mild,moderate and severe groups;according to age,the two groups were divided into < 40 years old,40-60 years old and > 60 years old groups.The IL-17C levels of different groups were compared.Results The IL-17C of UC group was significantly higher than that in control group (ng/L:251.72±90.49 vs.138.30±68.10,P < 0.05).There was no significant difference in IL-17C among UC patients of different degrees (P > 0.05).IL-17C level in healthy control group increased with age (P < 0.05),while in UC group IL-17C levels had no significant difference among different ages (all P > 0.05).There was no significant difference in different genders of two groups (both P > 0.05).Conclusion IL-17C may play a significant role in occurrence and development of UC,and has a certain clinical value in UC diagnosis.

关 键 词：白细胞介素-17C 溃疡性结肠炎 体外诊断 

分 类 号：R574.62[医药卫生—消化系统] R446.1[医药卫生—内科学]