基于Oncomine数据库分析PD-L1基因在头颈部癌中的表达及预后  

PD-L1 Expression in Head and Neck Cancer and Prognosis of Patients:An Analysis Based on Oncomine Database

作　　者：朱娅[1] 丁洁[1] 王莉[1] 王娟[1] 汪洋 Zhu Ya;Ding Jie;Wang Li;Wang Juan;Wang Yang(Department of Oncology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,Jiangsu,China)

机构地区：[1]南京医科大学第二附属医院肿瘤科,南京210011

出　　处：《肿瘤预防与治疗》2020年第4期300-306,共7页Journal of Cancer Control And Treatment

基　　金：南京医科大学科技发展基金(编号:2015 NJMUZD038)。

摘　　要：目的:研究程序性死亡因子配体1(programmed death factor 1,PD-L1/CD274)在头颈部癌中的表达情况,并分析其与临床病理特征及预后的相关性。方法:挖掘Oncomine数据库中关于PD-L1基因在头颈部癌中的相关数据,进行PD-L1表达量与头颈部癌临床生物学特性的相关分析,并利用数据库中生存数据进行生存分析。结果:Oncom-ine数据库中有关PD-L1基因癌组织/正常组织表达量的分析共176项,其中高表达的癌种共4项,低表达2项;在头颈部癌组织中,显著高表达1项。Meta分析显示,PD-L1在头颈部癌中呈现高表达,显著高于正常组织。在人乳头瘤病毒(human papillomavirus,HPV)阳性的HNC患者中PD-L1的表达显著高于HPV阴性HNC患者(0.38 vs 0.16,P=0.018),有远处转移的患者显著高于无转移者(1.36 vs 0.55,P=0.004)。生存分析显示PD-L1表达量与生存期无显著相关。结论:PD-L1在头颈部癌中表达水平高,与人乳头瘤病毒状态及肿瘤转移相关,与生存期不相关。Objective:To study the expression of programmed death factor 1(PD-L1/CD274)gene in head and neck cancer and analyze the relation of PD-L1 to clinicopathological features and prognosis of patients.Methods:Data of PD-L1 in head and neck cancer were collected from Oncomine database.The correlation between PD-L1 expression and clinical biological characteristics was analyzed.Survival analysis was conducted using data from the database.Results:Study results of 176 PD-L1 expression were found.Among them,4 kinds of tumors showed significantly higher expressed PD-L1 in cancer tissue,and 2 showed lower expression.In head and neck cancer,1 analysis indicated significant high expression.Meta-analysis indicated that PD-L1 expression in head and neck cancer was significantly higher than that in normal tissue;it in human papllomavirus(HPV)-positive specimens was significantly higher than that in HPV-negative specimens(0.38 vs 0.16,P=0.018);and it in patients with distant metastasis was significantly higher than that in those without metastasis(1.36 vs 0.55,P=0.004).Survival analysis indicated that PD-L1 expression was not significantly correlated to prognosis.Conclusion:PD-L1 is highly expressed in head and neck cancer,and its expression is associated with HPV and metastatic status.PD-L1 Expression is not related to the prognosis.

关 键 词：头颈部癌 Oncomine数据库 PD-L1 HPV 

分 类 号：R737.9[医药卫生—肿瘤] R720.4[医药卫生—临床医学]