Spontaneous porto-systemic shunts in liver cirrhosis:Clinical and therapeutical aspects  

作　　者：Silvia Nardelli Oliviero Riggio Stefania Gioia Marta Puzzono Giuseppe Pelle Lorenzo Ridola 

机构地区：[1]Department of Translational and Precision Medicine,“Sapienza”University of Rome,Rome 00185,Italy [2]Department of Interventional Radiology,Santa Maria Goretti Hospital,Latina 04100,Italy

出　　处：《World Journal of Gastroenterology》2020年第15期1726-1732,共7页世界胃肠病学杂志（英文版）

摘　　要：Spontaneous porto-systemic shunts(SPSS)are frequent in liver cirrhosis and their prevalence increases as liver function deteriorates,probably as a consequence of worsening portal hypertension,but without achieving an effective protection against cirrhosis'complications.Several types of SPSS have been described in the literature,each one associated with different clinical manifestations.In particular,recurrent or persistent hepatic encephalopathy is more frequent in patients with splenorenal shunt,while the presence of gastric varices and consequently the incidence of variceal bleeding is more common in gastrorenal shunt.In the advanced stage,the presence of large SPSS can lead to the so called“portosystemic shunt syndrome”,characterized by a progressive deterioration of hepatic function,hepatic encephalopathy and,sometimes,portal vein thrombosis.The detection of SPSS in patients with liver cirrhosis is recommended in order to prevent or treat recurrent hepatic encephalopathy or variceal bleeding.

关 键 词：Porto-systemic SHUNTS Liver cirrhosis Variceal bleeding Hepatic ENCEPHALOPATHY Portal VEIN THROMBOSIS Porto-systemic shunt syndrome 

分 类 号：R575.2[医药卫生—消化系统]