Effectiveness of very low-volume preparation for colonoscopy:A prospective, multicenter observational study  

作　　者：Marcello Maida Emanuele Sinagra Gaetano Cristian Morreale Sandro Sferrazza Giuseppe Scalisi Dario Schillaci Marco Ventimiglia Fabio Salvatore Macaluso Giovanni Vettori Giuseppe Conoscenti Concetta Di Bartolo Serena Garufi Domenico Catarella Michele Manganaro Clara Maria Virgilio Salvatore Camilleri 

机构地区：[1]Gastroenterology and Endoscopy Unit,S.Elia-Raimondi Hospital,Caltanissetta 93100,Italy [2]Gastroenterology and Endoscopy Unit,Istituto San Raffaele Giglio,Cefalu 90015,Italy [3]Gastroenterology and Endoscopy Unit,Santa Chiara Hospital,Trento 38014,Italy [4]Gastroenterology Unit,ARNAS Garibaldi,Catania 95100,Italy [5]Gastroenterology Unit,Basarocco Hospital,Niscemi 93015,Caltanissetta,Italy [6]Department of Internal Medicine,Villa Sofia-Cervello Hospital,Palermo 90100,Italy

出　　处：《World Journal of Gastroenterology》2020年第16期1950-1961,共12页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND The effectiveness of colonoscopy strictly depends on adequate bowel cleansing.Recently,a 1 L polyethylene glycol plus ascorbate(PEG-ASC)solution(Plenvu;Norgine,Harefield,United Kingdom)has been introduced on the evidence of three phase-3 randomized controlled trials,but it had never been tested in the real-life.AIM To assess the effectiveness and tolerability of the 1 L preparation compared to 4 L and 2 L-PEG solutions in a real-life setting.METHODS All patients undergoing a screening or diagnostic colonoscopy after a 4,2 or 1 L PEG preparation,were consecutively enrolled in 5 Italian centers from September 2018 to February 2019.The primary endpoints of the study were the assessment of bowel cleansing success and high-quality cleansing of the right colon.The secondary endpoints were the evaluation of tolerability,adherence and safety of the different bowel preparations.Bowel cleansing was assessed through the Boston Bowel Preparation Scale.Adherence was defined as consumption of at least 75%of each dose,while tolerability was evaluated through a semiquantitative scale.Safety was systematically monitored through adverse events reporting.RESULTS Overall,1289 met the inclusion criteria and were enrolled in the study.Of these,490 patients performed a 4 L-PEG preparation(Selgesse^■),566 a 2 L-PEG cleansing(Moviprep^■or Clensia^■)and 233 a 1 L-PEG preparation(Plenvu^■).Bowel cleansing by Boston Bowel Preparation Scale was 6.5±1.5 overall and 6.3±1.5,6.2±1.5,7.3±1.5(P<0.001)in the subgroups of 4 L,2 L and 1 L-PEG preparation,respectively.Cleansing success was achieved in 72.4%,74.1%and 90.1%(P<0.001),while a high-quality cleansing of the right colon in 15.9%,12.0%and 41.4%(P<0.001)for 4 L,2 L and 1 L-PEG preparation groups,respectively.The 1 L preparation was the most tolerated compared to the 2 and 4 L-PEG solutions in the absence of serious adverse events within any of the three groups.Multiple regression models confirmed 1 L PEG-ASC preparation as an independent predictor of overall cleansing s

关 键 词：COLONOSCOPY Bowel preparation Polyethylene glycol Polyethylene glycolplus ascorbate EFFECTIVENESS TOLERABILITY 

分 类 号：R574.62[医药卫生—消化系统]