TOLERABILITY

作品数：54被引量：145H指数：6
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相关领域：医药卫生更多>>
相关作者：曹思思邓阳张毕奎颜苗蔡骅琳更多>>
相关机构：中南大学中南大学湘雅二医院湖南中医药大学更多>>
相关期刊：《Open Journal of Psychiatry》《World Journal of Clinical Cases》《Translational Neurodegeneration》《World Journal of Clinical Oncology》更多>>
相关基金：国家自然科学基金广东省自然科学基金上海市教育委员会重点学科基金中国博士后科学基金更多>>
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Dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution
《World Journal of Gastrointestinal Oncology》2025年第1期101-109,共9页Mariarosaria D'Amato Gennaro Iengo Nicola Massa Chiara Carlomagno 
BACKGROUND Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(DPD),encoded by the DPYD gene.About 7%of the European population is a carrier of DPYD gene polymorphisms associat...
关键词：Dihydropyrimidine dehydrogenase DPYD polymorphisms FLUOROPYRIMIDINE Caucasian population Gastrointestinal cancers 
Correction to "Tolerability and first hints for potential efficacy of motor-cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint"
《Neuroprotection》2024年第4期329-329,共1页
Tolerability and first hints for potential efficacy of motor-cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders:A translational viewpoint
《Neuroprotection》2024年第3期228-242,共15页Svea-Solveig Mennen Maren Franta Martin Begemann Justus B.H.Wilke Roman Schroder Umer Javed Butt Jonathan-Alexis Cortés-Silva Umut Cakir Marie Gura Markus de Marees Vinicius Daguano Gastaldi Johannes Burtscher Julie Schanz Matthias Bohn Martin Burtscher Andreas Fischer Luise Poustka Peter Hammermann Markus Stadler Fred Luhder Manvendra Singh Klaus-Armin Nave Kamilla Woznica Miskowiak Hannelore Ehrenreich 
ERC Advanced Grant acronym BREPOCI,Grant/Award Number:101054369;ALTIBRAIN,Grant/Award Number:101043416;DFG,Grant/Award Number:TRR-274/12020-408885537。
Hypoxia is more and more perceived as pivotal physiological driving force,allowing cells in the brain and elsewhere to acclimate to lowered oxygen(O_(2)),and abridged metabolism.The mediating transcription program is ...
关键词：brain cognition ERYTHROPOIETIN functional hypoxia high-parameter flow cytometry immune cells oxygen saturation physical fitness plasticity 
Gastrointestinal tolerability of organic infant formula compared to traditional infant formula: A systematic review
《World Journal of Clinical Pediatrics》2024年第1期125-140,共16页Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi Mohamed Basiony Hamza 
BACKGROUND Infants'nutrition significantly influences their growth,development,and overall well-being.With the increasing demand for organic infant formula driven by the perception of health benefits and growing aware...
关键词：Organic infant formula Traditional infant formula Gastrointestinal tolerability Formula ingredients Digestive health Infant nutrition Organic farming 
Safety, Tolerability and Anti-Diarrhoeal Activity of “Diarra”, a Preparation of Medicinal Plants Used in Ivorian Traditional Medicine
《Pharmacology & Pharmacy》2023年第10期428-440,共13页Kouakou Etienne Effo Yacouba Adebo Adehouni Gbongué Eric Tia Amenan Geneviève Irié-N’Guessan N’Doua Gisèle Kouakou Siransy 
Background: “Diarra”, a traditional herbal remedy made from five (5) medicinal plants, might be endowed with anti-diarrhoeal properties according to its owner. However, scientific evidence of its safety, tolerabilit...
关键词：SAFETY TOLERABILITY ANTIDIARRHEAL Diarra Traditional Medicine 
Progress in the Study of Vonoprazan Fumarate vs. Proton Pump Inhibitors in the Treatment of Gastroesophageal Reflux Disease
《Yangtze Medicine》2023年第2期95-104,共10页Yuanmei Dai Baofeng Liu Xiaohui Shen Lei Huang 
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disease, and proton pump inhibitors (PPIs) have been recommended as the first-line treatment for GERD. In recent years, studies on vonoprazan fumarat...
关键词：Vonoprazan Fumarate Proton Pump Inhibitors Gastroesophageal Reflux Disease EFFICACY Safety TOLERABILITY Long-Term Application 
An open-label multiyear study of sargramostim-treated Parkinson’s disease patients examining drug safety,tolerability,and immune biomarkers from limited case numbers
《Translational Neurodegeneration》2023年第1期529-545,共17页Katherine E.Olson Mai M.Abdelmoaty Krista L.Namminga Yaman Lu Helen Obaro Pamela Santamaria R.Lee Mosley Howard E.Gendelman 
supported by National Institute of Neurological Disorders and Stroke Grant 5 R01NS034239-25 and private donations provided through the University of Nebraska Foundation.
Background The clinical utility and safety of sargramostim has previously been reported in cancer,acute radiation syndrome,autoimmune disease,inflammatory conditions,and Alzheimer’s disease.The safety,tolerability,an...
关键词：Parkinson’s disease Granulocyte-macrophage colony-stimulating factor Unified Parkinson’s Disease Rating Scale Regulatory T cells NEUROPROTECTION Sargramostim therapy 
Freehand transperineal prostate biopsy with a coaxial needle under local anesthesia:Experience from a single institution in Malaysia
《Cancer Pathogenesis and Therapy》2023年第1期33-39,共7页Ing Soon Ngu Ming Soen Ngooi Han Kun Ng Kenny Tang Long Tee Chee Hoong Loo Meng Shi Lim 
Background Freehand transperineal prostate biopsy(TPPBx)using a coaxial needle technique offers an alternative to probe-mounted freehand or template-guided techniques in the diagnosis of prostate cancer(PCa).It only r...
关键词：Prostate cancer FREEHAND Transperineal biopsy of prostate Coaxial needle TRUS biopsy PSA density Pain tolerability 
Safety,tolerability,and pharmacokinetics of VV116,an oral nucleoside analog against SARS-CoV-2,in Chinese healthy subjects被引量：18
《Acta Pharmacologica Sinica》2022年第12期3130-3138,共9页Hong-jie Qian Yu Wang Meng-qi Zhang Yuan-chao Xie Qing-qing Wu Li-yu Liang Ye Cao Hua-qing Duan Guang-hui Tian Juan Ma Zhuo-bing Zhang Ning Li Jing-ying Jia Jing Zhang Haji Akber Aisa Jing-shan Shen Chen Yu Hua-liang Jiang Wen-hong Zhang Zhen Wang Gang-yi Liu 
he studies were sponsored by Vigonvita Life Science Co.,Ltd and Shanghai JunTop Biosciences Co.,Ltd.This work was partially supported by the National Key Research and Development Program of China(No.2021YFC0865000);the Lingang Laboratory(No.LG202103-04-04);the 2020 ANSO Collaborative Research Project(No.ANSO-CR-SP-2020-03);Shanghai Science and Technology Committee(No.21S11903100).
VV116(JT001)is an oral drug candidate of nucleoside analog against SARS-CoV-2.The purpose of the three phase I studies was to evaluate the safety,tolerability,and pharmacokinetics of single and multiple ascending oral...
关键词：VV116 nucleoside analog SARS-CoV-2 SAFETY PHARMACOKINETICS healthy subjects 
Hepatitis C virus burden:Treating and educating people without prejudice被引量：1
《World Journal of Hepatology》2022年第7期1495-1503,共9页Elettra Merola Elisa Menotti Giovanna Branz Andrea Michielan Sonia Seligmann Annora Ratti Flora Agugiaro Luisa Moser Giovanni Vettori Anna Franceschini William Mantovani Riccardo Pertile Giovanni de Pretis Cecilia Pravadelli 
Hepatitis C virus(HCV)infection has a worldwide incidence of 1.1%.In Italy,60%of people who inject drugs(PWIDs)and are receiving assistance for substance use disorder are infected with HCV.However,this subset of patie...
关键词：Hepatitis C virus Service for substance use disorder Direct-acting antivirals Sustained virologic response COMPLIANCE TOLERABILITY 
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