茶多酚磁性微胶囊的制备条件优化和性能分析  

Optimization and characterization of magnetic tea polyphenols microcapsules

作　　者：李超[1] 李保国[1] 朱传辉[1] 孟祥[1] LI Chao;LI Baoguo;ZHU Chuanhui;MENG Xiang(School of Energy and Power Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学能源与动力工程学院,上海200093

出　　处：《食品与发酵工业》2020年第9期128-134,共7页Food and Fermentation Industries

基　　金：上海市教委科研创新项目(14ZZ133);上海市助推计划(ZB1307LG);上海市联盟计划(LM2018079)。

摘　　要：茶多酚在抗癌方面具有多种生物和药理作用,但在空气中很容易被氧化,故长期作用受到限制。微胶囊化封装技术可以帮助克服这些缺点。肿瘤血管内栓塞疗法通过微胶囊栓塞剂,阻塞肿瘤细胞增殖需要的养分以及氧气,抑制肿瘤生长。同时,通过磁性微胶囊的药物靶向缓释技术,向癌靶区释放抗癌药物,杀伤癌细胞,毒副作用小,治疗效果显著,是一种治疗癌症的新方法。磁性微胶囊的性能,如包覆率和粒径,受到多种因素的影响。利用Box-Behnken响应曲面的实验设计优化了磁性微胶囊的配方:海藻酸钠质量浓度18.36 g/L,电压6.222 kV,推进速度80 mm/h。在此条件下,磁性微胶囊的包覆率为87.836 2%,平均尺寸为217.67μm。茶多酚缓释持续20 h以上,有较好的缓释性能。功能性验证显示,优化后的磁性微胶囊相比于优化前,具有更好的缓释性和抗氧化性。Tea polyphenols exhibited various biological and pharmacological effects on cancer prevention. However, they were easily oxidized in the air, which restricted its long-term effects. Encapsulation technology was one of the most effective methods to overcome these drawbacks. Tumor endovascular embolization therapy could block the nutrients and oxygen for tumor cell proliferation and inhibited tumor growth through microcapsule embolization. Meanwhile, the magnetic microcapsule released anti-cancer drugs into the target area to kill cancer cells. Due to little side effects and remarkable therapeutic effects, this therapy was regarded as a new method to treat cancer. The properties of magnetic microcapsules, such as encapsulation efficiency and particle size, were affected by many factors. This study optimized the formula of tea polyphenol magnetic microcapsules by using the experimental design of BBD-RSM. The optimal formula for the preparation of magnetic microcapsules was as follows: the concentration of sodium carboxymethyl cellulose was 1.863 9%, the voltage was 6.222 kV and the propulsion speed was 80 mm/h, respectively. The encapsulation efficiency of magnetic microcapsules was 87.836 2% and the average particle size was 217.67 μm. The magnetic microcapsules had good antioxidant property, and the release of the magnetic microcapsules was sustained for more than 20 h. The result of functional verification showed that the optimized magnetic microcapsules had better slow-release performance and anti-oxidation property.

关 键 词：茶多酚 磁性微胶囊 磁响应性 响应面分析 缓释 

分 类 号：TQ460.1[化学工程—制药化工]