嘧啶酮-肉桂酸杂合体的合成及其抗氧化活性研究  

Synthesis and Antioxidant Activity of Pyrimidinone-Cinnamic Acid Hybrid

作　　者：李静 宁卫红[1,2] 路东亮 谢永荣 李琰[3] LI Jing;NING Weihong;LU Dongliang;XIE Yongrong;LI Yan(School of Chemistry and Chemical Engineering,Gannan Normal University,Ganzhou 341000,China;Key Laboratory of Jiangxi University for Functional Materials Chemistry,Gannan Normal University,Ganzhou 341000,China;Shaoxing University,Shaoxing 312000,China)

机构地区：[1]赣南师范大学化学化工学院,江西赣州341000 [2]赣南师范大学江西省高等学校功能材料化学重点实验室,江西赣州341000 [3]绍兴文理学院,浙江绍兴312000

出　　处：《赣南师范大学学报》2020年第3期56-59,共4页Journal of Gannan Normal University

基　　金：江西省教育厅基金(GJJ160955);江西省功能材料化学重点实验室开放课题(FMC16203);赣州市科技计划项目。

摘　　要：为改善嘧啶酮和天然产物多酚类化合物的生物活性,运用药物杂合的设计理念合成了4个新的嘧啶酮-肉桂酸杂合体药物分子.利用核磁共振表征化合物的结构,通过清除DPPH自由基的方法研究其抗氧化活性.结果表明:4个化合物都具有显著的抗氧化活性,特别是化合物6a的抗氧化活性是天然抗氧化剂姜黄素的3.5倍.In order to improve the biological activity of pyrimidinone and natural product polyphenols,four new pyrimidinone-cinnamic acid hybrid drug molecules were designed and synthesized using the concept of drug hybrid.The structure of compounds were identified by NMR.Their antioxidant activities were systematically characterized by scavenging DPPH radical.The results show that all four compounds have significant activities,especially compound 6a,whose antioxidant activity is 3.5 times that of curcumin.

关 键 词：杂合体 DPPH自由基 抗氧化活性 

分 类 号：R285.5[医药卫生—中药学]