Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation,apoptosis,and oxidative stress  

作　　者：Feng Han Meng Dou Yuxiang Wang Cuixiang Xu Yang Li Xiaoming Ding Wujun Xue Jin Zheng Puxun Tian Chenguang Ding 

机构地区：[1]Department of Kidney Transplantation,Hospital of Nephropathy,First Affiliated Hospital of Medical College of Xi'an Jiaotong University,Xi'an 710061,China [2]Center of Shaanxi Provincial Clinical Laboratory,Shaanxi Provincial People's Hospital,Xi'an 710061,China [3]Institute of Organ Transplantation,Xi'an Jiaotong University,Xi'an 710061,China

出　　处：《Acta Biochimica et Biophysica Sinica》2020年第2期125-132,共8页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the Fundamental.Research Funds for the Central Universities(No.xij2018091);the Major Clinical Research Projects of the First Affiliated Hospital of Xi'an Jjiaotong University(No.XJTU1AF-CRF-2015-005);the Scientific and Technological Breakthrough in Social Development of Shaanxi Province(No.2016SF-246);the China Organ Transplan-tation Development Foundation‘Elite Proiect’(No.2019JYJH04);the National Natural Science Foundation of China(Nos.81670681,81760137,and 81870514);the Major Basic Research Project of Shaanxi Province(No.2017ZDJC-09).

摘　　要：Cordycepin(3-deoxyadenosine)is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis,species of the fungal genus Cordyceps.It has traditionally been a prized Chinese folk medicine for the human well-being.However,the actions of cordycepin against renal ischemia/reperfusion injury(/R)are still unknown.In the present study,rats were subject to VR and cordycepin was intragastrically administered for seven consecutive days before surgery to investigate the effects and mechanisms of cordycepin against renal/R injury.The test results of kidney and peripheral blood samples of experimental animals showed that cordycepin significantly decreased serum blood urea nitrogen and creatinine levels and markedly attenuated cell injury.Mechanistic studies showed that cordycepin significantly regulated inflammation,apoptosis,and oxidative stress.These data provide new insights for investigating the natural product with the nephroprotective effect against I/R,which should be developed as a new therapeutic agent for the treatment of I/R in the future.

关 键 词：CORDYCEPIN RENAL ISCHEMIA/REPERFUSION injury iflammation APOPTOSIS OXIDATIVE stress 

分 类 号：R692[医药卫生—泌尿科学]