CORDYCEPIN

作品数：28被引量：122H指数：7
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相关作者：李婧姜汉英马传荣汪燕姜漠英更多>>
相关机构：华中科技大学更多>>
相关期刊：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《Synthetic and Systems Biotechnology》《Food Science and Human Wellness》《Journal of Cancer Therapy》更多>>
相关基金：国家自然科学基金中国博士后科学基金山东省科技发展计划项目山东省自然科学基金更多>>
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16S amplicon sequencing and untargeted metabolomics reveal changes in rumen microorganisms and metabolic pathways involved in the reduction of methane by cordycepin被引量：1
《Journal of Integrative Agriculture》2025年第4期1310-1326,共17页Haokai Ma Dengke Liu Rui Liu Yang Li Modinat Tolani Lambo Baisheng Dai Weizheng Shen Yongli Qu Yonggen Zhang 
financially supported by the National Key Research and Development Program of China(2023YFD2000701);the Natural Science Foundation of Heilongjiang Province,China(YQ2023C011);the Key Research and Development Program of Heilongjiang Province,China(Grant no.2022ZX01A24);the Key Laboratory of Low-carbon Green Agriculture in Northeastern China,Ministry of Agriculture and Rural Affairs of China(LCGANE14)。
As a major contributor to methane production in agriculture,there is a need for a suitable methane inhibitor to reduce ruminant methane emissions and minimize the impact on the climate.This work aimed to explore the i...
关键词：CORDYCEPIN in vitro rumen fermentation rumen microbiome METABOLOME methane production 
Mechanism of action of cordycepin in the treatment of hepatocellular carcinoma via regulation of the Hippo signaling pathway
《Food Science and Human Wellness》2024年第2期1040-1054,共15页Xiaomin Li Qing Liu Songyu Xie Xiaoping Wu Junsheng Fu 
supported by the National Natural Science Foundation of China(81503187)。
Hepatocellular carcinoma(HCC)is one of the common most malignant tumors.This study aimed to determine the in vitro and in vivo anticancer activity of cordycepin and elucidate its mechanism of action.The results of in ...
关键词：CORDYCEPIN Hepatocellular carcinoma Hippo signaling pathway GBP3 ETV5 
Engineering Komagataella phaffii to biosynthesize cordycepin from methanol which drives global metabolic alterations at the transcription level被引量：1
《Synthetic and Systems Biotechnology》2023年第2期242-252,共11页Huiping Tan Liang Wang Huiguo Wang Yanghao Cheng Xiang Li Huihui Wan Chenguang Liu Tian Liu Qian Li 
support from Open Funding Project of State Key Laboratory of Microbial Metabolism(No.MMLKF20-09);Research Project of Applied Basic Research Program of Department of Science&Technology of Liaoning Province(2022JH2/101300137);the Project of Natural Science Foundation of Liaoning Province(2022-KF-15-02);Science Research Foundation of Educational Department of Liaoning Province(No.J2020099).
Cordycepin has the potential to be an alternative to the disputed herbicide glyphosate.However,current laborious and time-consuming production strategies at low yields based on Cordyceps militaris lead to extremely hi...
关键词：CORDYCEPIN Komagataella phaffii Fermentation optimization TRANSCRIPTOME 
Rapid detection of cordycepin in food by surface-enhanced Raman technique被引量：1
《Journal of Future Foods》2023年第1期24-28,共5页Yiwei Wang Bin Zhang Meijuan Guo Chenyuan Wang Qingbo Wang Lantian Zhang Yan Zhang 
In this paper,a method for rapid detection of cordycepin in food was established based on surface-enhanced Raman spectroscopic analysis method.The surface-enhanced Raman substrates were screened and the Raman detectio...
关键词：CORDYCEPIN Surface-enhanced Raman spectroscopy(SERS) Gold nanocolloid 
Design,synthesis,and biological evaluation of a series of novel cordycepin derivatives被引量：1
《Journal of Chinese Pharmaceutical Sciences》2022年第1期55-67,共13页Lijuan Jiang Tingting Cao Ruoyi Yang Ying Li Lin Dong Shufan Yin 
Research Basic Ability Enhancement Project of Young and Middle-aged Teachers in Guangxi Universities(Grant No.2019KY0166);the Project of Guangxi University for Nationalities(Grant No.2018MDYB006,2018XJGY46)。
In this study,a novel series of cordycepin derivatives with benzenesulfonamido groups at the 6-position of the purine ring were synthesized and their antitumor activity was evaluated.We revealed the structural moietie...
关键词：CORDYCEPIN DERIVATIVES SYNTHESIS Biological activity research 
Cultivated Cordyceps: A Tale of Two Treasured Mushrooms被引量：1
《Chinese Medicine and Culture》2021年第4期221-227,共7页Anawinla Ta Anyu Wen-Hui Zhang Qi-He Xu 
Ophiocordyceps sinensis and Cordyceps militaris both contain many bioactive compounds that confer potential therapeutic benefits. This review discusses the possible use of cultivated C. militaris as an effective subst...
关键词：CORDYCEPIN cordyceps militaris ophiocordyceps sinensis 
Matrix-assisted laser desorption ionization mass spectrometry based quantitative analysis of cordycepin from Cordyceps militaris
《Journal of Pharmaceutical Analysis》2021年第4期499-504,共6页Jian Chen Hai-Fang Li Guozhu Zhao Jin-Ming Lin Xiangwei He 
financially supported by Fundamental Research Funds for the Central Universities(Grant No.2019ZY31);the National Natural Science Foundation of China(Grant Nos.21775086 and 31770110)。
Cordycepin,which has great immunomodulatory activities such as anticancer,antifungal,antivirus,antileukemia and lipid-lowering ones,is the secondary metabolite of Cordyceps militaris(C.militaris).Liquid submerged ferm...
关键词：CORDYCEPIN MALDI-MS Isotope internal standard Quantitative analysis Liquid fermentation 
Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling被引量：13
《Chinese Journal of Natural Medicines》2020年第5期345-355,共11页LI Xue-Ying TAO Hong JIN Can DU Zhen-Yun LIAO Wen-Feng TANG Qing-Jiu DING Kan 
Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDA12010302);National Natural Science Foundation of China(No. 31230022);Program of Shanghai Subject Chief Scientist(No. 16XD1404500)。
Cordycepin(3′-deoxyadenosine) from Cordyceps militaris has been reported to have anti-tumor effects. However, the molecular target and mechanism underlying cordycepin impeding pancreatic cancer cell growth in vitro a...
关键词：CORDYCEPIN FGFR2 Apoptosis Pancreatic cancer Ras/Erk 
Overexpression of ribonucleotide reductase small subunit,RNRM,increases cordycepin biosynthesis in transformed Cordyceps militaris被引量：2
《Chinese Journal of Natural Medicines》2020年第5期393-400,共8页ZHANG Han WANG Yu-Xian TONG Xin-Xin Yokoyama Wallace CAO Jing WANG Fang PENG Cheng GUO Jin-Lin 
the Natural Sciences Foundation of China Science (Nos.81872959, 81373920,30801522);Sichuan Province Youth Innovation Team Fund (No.19CXTD0055);China Scholarship Fund (No. 201708570027)。
Cordycepin was the first adenosine analogue used as an anticancer and antiviral agent, which is extracted from Cordyceps militaris and hasn’t been biosynthesized until now. This study was first conducted to verify th...
关键词：Cordycepin biosynthesis Ribonucleotide reductases gene Agrobacterium tumefaciens-mediated transfection 
Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation,apoptosis,and oxidative stress被引量：15
《Acta Biochimica et Biophysica Sinica》2020年第2期125-132,共8页Feng Han Meng Dou Yuxiang Wang Cuixiang Xu Yang Li Xiaoming Ding Wujun Xue Jin Zheng Puxun Tian Chenguang Ding 
This work was supported by the grants from the Fundamental.Research Funds for the Central Universities(No.xij2018091);the Major Clinical Research Projects of the First Affiliated Hospital of Xi'an Jjiaotong University(No.XJTU1AF-CRF-2015-005);the Scientific and Technological Breakthrough in Social Development of Shaanxi Province(No.2016SF-246);the China Organ Transplan-tation Development Foundation‘Elite Proiect’(No.2019JYJH04);the National Natural Science Foundation of China(Nos.81670681,81760137,and 81870514);the Major Basic Research Project of Shaanxi Province(No.2017ZDJC-09).
Cordycepin(3-deoxyadenosine)is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis,species of the fungal genus Cordyceps.It has traditionally been a prized Chi...
关键词：CORDYCEPIN RENAL ISCHEMIA/REPERFUSION injury iflammation APOPTOSIS OXIDATIVE stress 
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